Protein Alignment Pten and gak

DIOPT Version :10

• Sequence 1: NP_477422.2
• Gene: Pten / 43991
• FlyBaseID: FBgn0026379
• Length: 514
• Species: Drosophila melanogaster
• Sequence 2: XP_009299489.2
• Gene: gak / 100151158
• ZFINID: ZDB-GENE-041210-358
• Length: 1278
• Species: Danio rerio
• Alignment Length: 605
• Identity: 142/605 - (23%)
• Similarity: 240/605 - (39%)
• Gaps: 157/605 - (25%)

  Fly     1 MANTISLMSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLL 65
            :.|.....|.||::|.|      ..|| ||||:||...:..|.:|| :.:|...:|.:|||...|
Zfish   380 LTNIKDTSSKVIQSVAS------YAKG-DLDLSYITSRLAVMSFPA-EGVESAIKNNIEDVRLFL 436

  Fly    66 EENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAV 130
            :..||.||.:||| |:|||..|:|..||:...:.....||::.:...|.::..|||:|..|:..|
Zfish   437 DSRHAGHYAVYNL-SKRSYRPARFHNRVSECGWQPRRAPTLKNLYSICKNMHQWLKQDQRNICIV 500

  Fly   131 HCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSS-- 193
            ||..|:..:..::||:|.|..:..:|:.|:..:..||..  .|:: .|.:||::|...::...
Zfish   501 HCLDGRAASAVVVCAFLCFCRLFSTAEAAVYMFSMKRCP--PGIS-ASHKRYIEYMCDMMAEEPI 562

  Fly   194 VPYSKVSLNVCEIRFSESSCVQNLGMVE--------------CSISVLHDS-ATENAKPDRLKTL 243
            :|:||            ...::::.|..              |.:.|..:. ||.:.:.||::..
Zfish   563 IPHSK------------PITIRSVAMTPVPLFNKQRNGCRPFCEVYVGDERVATTSQEYDRMRDF 615

  Fly   244 PIDFQKSFVLTIKPSIPVSGDVKF-----------ELTKKSPDKIICHFWLNTFFV-RNYSPCES 296
            .::..::   .|..:|.|.|||..           .|..|.....:.....:|.|| ||.|
Zfish   616 KMEDGRA---EIPLNITVQGDVLIVIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNAS---- 673

  Fly   297 DGTVNKYIHTLSKSEID--DVHKDSEHKRFSEEFKISIVFEA-------------ENF------- 339
              ||.     .:|.::|  |:     .:::.:.|::.:..|.             |||
Zfish   674 --TVK-----FAKYDLDACDI-----QEKYPDLFQVHVNVEVEPQDRPSNKTPPWENFATKGLNP 726

  Fly   340 -----SNDVQAE--------------------ASEKERNENVLNFERSDYDSLSPNCYAEKKVLT 379
                 |.|.|.|                    ||:..::||..:..:::.||.||.
Zfish   727 KILFSSRDEQQEILTKFGKPELPRQPGSTACYASDPPQSENSPDDPQTESDSPSPQ--------- 782

  Fly   380 AIVNDNTTKSQTIETL---------DHKDIVTKIQYDTSTNSKNTSTACKRKQPNSKTLLPSLND 435
               :.:|..:...:||         ||.|.....|.|.|..|:..|.:      .|..:..:|:.
Zfish   783 ---STDTNANNFFQTLDWEDTSRHFDHADGHLDDQEDLSGGSEEESVS------YSAPIEGTLSR 838

  Fly   436 STKEEIKRNHIFNQPSIKKTDL--IKWQNSE---VHITSDTRSINENKNINYNSYITCKQSSPKF 495
            .|.|.:......|.|...:.|.  :...|||   ....|..:|...|.|: .|..:...|::...
Zfish   839 DTSEPLFEADFTNTPPEAQPDTEDLLGLNSEPGPAVPESGLKSSASNSNL-LNDLLFAPQTNTVP 902

  Fly   496 NCGTED--GEEDWESGESTY 513
            :...||  ||   ::||..:
Zfish   903 SASNEDLMGE---DAGEDLF 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_477422.2	PTP_PTEN	31..189	CDD:350359	53/157 (34%)
		PTEN_C2	196..335	CDD:463081	29/167 (17%)
gak	XP_009299489.2	None