DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and pten

DIOPT Version :9

Sequence 1:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster
Sequence 2:	NP_001116943.1	Gene:	pten / 100144716	XenbaseID:	XB-GENE-491433	Length:	402	Species:	Xenopus tropicalis

Alignment Length:	435	Identity:	173/435 - (39%)
Similarity:	240/435 - (55%)	Gaps:	71/435 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQH 72
            |:.:|:..||:.:.||:|.|:|||||||..||||||:|| ::|||::||.::||.:.|:..|..|
Frog     1 MTAIIKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPA-ERLEGVYRNNIDDVVRFLDSKHKNH 64

  Fly    73 YKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKG 137
            |||||||:||.||..||..|||.|||:|||||.:|||:.||.|:|.||.| :.||.|:|||||||
Frog    65 YKIYNLCAERHYDTNKFSCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSE-NENVAAIHCKAGKG 128

  Fly   138 RTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLN 202
            |||.||||||:..|....|.|||.:|.|.||:|:||||||||||||.|:|.|:.:::.|..|.|.
Frog   129 RTGVMICAYLLHRGKFPRAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNNLEYRPVPLL 193

  Fly   203 VCEIR------FSESSCVQNLGMVECSISVLHDSATENAKPDRL-KTLPIDFQKSFVLTIKPSIP 260
            ..:|.      ||.|:|.....:.:..:.:.    |..|.|.|: |.:..||.:        .:|
Frog   194 FHKIEFETIPMFSGSTCNPQFVVYQLKVKIF----TSTAGPKRIEKLMYFDFPQ--------PLP 246

  Fly   261 VSGDVKFELTKKSPDKI-----ICHFWLNTFFV---RNYSPCESDGTV----------------- 300
            |.||:|.|...|. :|:     :.|||:||||:   ..||....:||:
Frog   247 VCGDIKVEFFHKQ-NKVMKKEKMFHFWINTFFIPGPEEYSEKVENGTLVGEQELDGIYSTERSDN 310

  Fly   301 -NKYIH-TLSKSEIDDVHKDSEHKRFSEEFKISIVF--EAENFSNDVQAEASEKERNENVLNFER 361
             .:|:. ||:|:::|..:||..::.||..||:.:.|  ..|..||      ||...:.:|    .
Frog   311 DKEYLTLTLTKNDLDKANKDKANRLFSPNFKVKLFFTKTVEESSN------SEASSSTSV----T 365

  Fly   362 SDYDSLSPNCYAEKKVLTAIVNDNTTKSQTIETLDHKDI--VTKI 404
            .|.....|:.|.        .:|.|......|..|...|  :||:
Frog   366 PDVSDNEPDHYR--------YSDTTDSDPENEPFDEDQITQITKV 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	65/108 (60%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	46/174 (26%)
pten	NP_001116943.1	PTP_PTEN	24..180	CDD:350359	100/157 (64%)
pten	NP_001116943.1	PTEN_C2	187..348	CDD:371036	46/173 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6974
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H265
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2870
OMA	1	1.010	-	-		QHG52467
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001369
OrthoInspector	1	1.000	-	-		oto103866
Panther	1	1.100	-	-	LDO	PTHR12305
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1027
SonicParanoid	1	1.000	-	-		X965
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100