DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep5 and Septin14

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_083102.1	Gene:	Septin14 / 74222	MGIID:	1921472	Length:	429	Species:	Mus musculus

Alignment Length:	404	Identity:	228/404 - (56%)
Similarity:	291/404 - (72%)	Gaps:	19/404 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VTEKKTQEVATKVP------------RLLQLGGHVGFDTLPDQLVNKSVQNGFSFNILCIGETAL 57
            :.||.|.   |.||            |.|...||.||:.||.||||||:|.||||||||:|||.:
Mouse     1 MAEKPTN---TSVPIPGSEDPQKENIRCLSTLGHFGFECLPTQLVNKSIQKGFSFNILCVGETGI 62

  Fly    58 GKSTLMDTLFNTSFGSTPSPHNLPNVKLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKAL 122
            ||:||::|||||:...|.|.|....|.|...||||.|.|:.|:|||..|:|||||:||..||:.:
Mouse    63 GKTTLINTLFNTNLKETKSSHFYSKVGLTVKTYELLERNIPLRLTVVKTVGYGDQINKEASYQPV 127

  Fly   123 VEYVDSQFEAYLQEELKIQRAMASAHDGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVI 187
            |:|:|:||||||||||||:|::|..||.|:|.|||||.||||.||::||:.||.:|.||||||:|
Mouse   128 VDYLDAQFEAYLQEELKIKRSLADYHDSRIHVCLYFITPTGHSLKSLDLLTMKSIDRRVNIIPLI 192

  Fly   188 AKADTISKSELSGFKERIMDELRRNNVSIYQFPMDDETVSETNAAMNGHLPFAVVGSTEFVKVAG 252
            ||||::||::|..||..||.||..|.:.||||.:|||..::.|:  :|.||||||||.|.|||..
Mouse   193 AKADSLSKNDLQRFKNNIMSELNSNGIQIYQFQVDDEASAQVNS--SGLLPFAVVGSMEEVKVGK 255

  Fly   253 KQVRARQYPWGAVHIENEAHCDFVKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDS 317
            :.||.|.||||.:.:|||.||||||||::|:.||||||::||||:|||.:|..|||::||.|...
Mouse   256 RMVRGRHYPWGVLQVENENHCDFVKLRDLLLSTNMEDLKDQTHTQHYECYRSNRLQKLGFSDTGP 320

  Fly   318 NNQPVSFQQTFESKRSD-HLACLQAKEEEVRQMFVQRVKQKENELKDNEKELHTKFDRLKREHLE 381
            :|:|||||:.:|:||.: |..| |.:|||::|.|:||||:||...||.||||..||:.|||...|
Mouse   321 DNRPVSFQEMYEAKRREFHNQC-QKEEEELKQTFMQRVKEKELTFKDAEKELQDKFEHLKRIQQE 384

  Fly   382 EKAQLEEARRQLEE 395
            |..:|||.||:|||
Mouse   385 EILKLEEERRKLEE 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	217/369 (59%)
		CDC_Septin	43..311	CDD:206649	160/267 (60%)
		BAR	<252..405	CDD:299863	83/145 (57%)
Septin14	NP_083102.1	CDC3	33..386	CDD:227352	209/355 (59%)
		CDC_Septin	48..314	CDD:206649	160/267 (60%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	58..65		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	110..113		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	193..196		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51948
OrthoDB	1	1.010	-	-		D294076at33208
OrthoFinder	1	1.000	-	-		FOG0000793
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101834
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930