DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep5 and septin12

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_031748559.1	Gene:	septin12 / 594940	XenbaseID:	XB-GENE-5894593	Length:	892	Species:	Xenopus tropicalis

Alignment Length:	314	Identity:	128/314 - (40%)
Similarity:	201/314 - (64%)	Gaps:	21/314 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QEVATKVPRLLQLG-------GHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFN 68
            |.:|...|...:.|       |:||.|.:.||:..|:::|||.|||:.:|::.||||||::|||.
Frog   572 QNLARPEPEPQRCGDIGQEPIGYVGIDAVLDQMRRKAMKNGFEFNIMVVGQSGLGKSTLVNTLFK 636

  Fly    69 T-----SFGSTPSPHNLP-NVKLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVD 127
            :     |.|:|     :| .|:|.|.:..::|..:.::|||.||.|:|||:|..:.:..:::|:.
Frog   637 SKVIRKSPGAT-----IPKTVELNAVSQVVEERGMEMRLTVIDTPGFGDQINNQNCWDPIIKYIH 696

  Fly   128 SQFEAYLQEELKIQRAMASAHDGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADT 192
            .|:|.||:||:.|.| .....|.|:|:|:|||.||||.|:.:||..||:|...||::||||||||
Frog   697 EQYEKYLREEILINR-KRRIPDSRIHSCIYFIPPTGHWLRPLDLEFMKRLGRIVNVVPVIAKADT 760

  Fly   193 ISKSELSGFKERIMDELRRNNVSIYQFP-MDDETVSE-TNAAMNGHLPFAVVGSTEFVKVAGKQV 255
            ::..|...||:||..:|:.:.:|:|..| :|::.|.. .|..:...:||||||:.|..:|.|::|
Frog   761 LTLEEREEFKQRIRKDLQTHGISVYPQPELDEDPVDALVNDKIREKIPFAVVGTDEEHQVNGRKV 825

  Fly   256 RARQYPWGAVHIENEAHCDFVKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQ 309
            ..|:..||.:.:||.|||:|..||::|||:|::||::.||..|||.:|..||.:
Frog   826 LGRKTKWGVIEVENTAHCEFANLRDLLIRSNLQDLKDITHNIHYETYRVSRLNE 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	124/293 (42%)
		CDC_Septin	43..311	CDD:206649	117/275 (43%)
		BAR	<252..405	CDD:299863	27/58 (47%)
septin12	XP_031748559.1	PRK10263	<231..>401	CDD:236669
septin12	XP_031748559.1	CDC_Septin	611..881	CDD:206649	117/275 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920