DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sep5 and Septin6

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001170795.1	Gene:	Septin6 / 56526	MGIID:	1888939	Length:	434	Species:	Mus musculus

Alignment Length:	412	Identity:	266/412 - (64%)
Similarity:	324/412 - (78%)	Gaps:	9/412 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RLLQLGGHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTSFGSTPSPHNLPNV 83
            |.:.|.||||||:||||||||||..||.|||||:|||.|||||||||||||.|...|:.|..|.|
Mouse    15 RTVPLAGHVGFDSLPDQLVNKSVSQGFCFNILCVGETGLGKSTLMDTLFNTKFEGEPATHTQPGV 79

  Fly    84 KLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEELKIQRAMASAH 148
            :|::|||:||||||.||||:..|:|:|||:||.||||.:||::|:||||||||||||:|.:.|.|
Mouse    80 QLQSNTYDLQESNVGLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHSYH 144

  Fly   149 DGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKERIMDELRRNN 213
            |.|:|.|||||.||||.||::|||.||:||::|||||||||:|.||||||:.||.:|..||..|.
Mouse   145 DSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPVIAKSDAISKSELAKFKIKITSELVSNG 209

  Fly   214 VSIYQFPMDDETVSETNAAMNGHLPFAVVGSTEFVKVAGKQVRARQYPWGAVHIENEAHCDFVKL 278
            |.|||||.|||:|||.|..||.|||||||||||.||:..|.:||||||||.|.:|||||||||||
Mouse   210 VQIYQFPTDDESVSEINGTMNAHLPFAVVGSTEEVKIGNKMMRARQYPWGTVQVENEAHCDFVKL 274

  Fly   279 REMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNNQPVSFQQTFESKRSDHLACLQAKE 343
            ||||||.||||||||||.|||||:|:.:|::|||.|.|.:::|.|.|:|:|:||::.|..||.||
Mouse   275 REMLIRVNMEDLREQTHARHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKE 339

  Fly   344 EEVRQMFVQRVKQKENELKDNEKELHTKFDRLKREHLEEKAQLEEARRQLEEDCQELQRRR---- 404
            ||:|||||||||:||.|||:.|||||.||||||:.|.|||.:||:.::.|:|:....::|:
Mouse   340 EEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQEEKKKLEDKKKCLDEEMNAFKQRKAAAE 404

  Fly   405 -LQ----MANGSHTLTLGRGKK 421
             ||    .|.||.||...:.||
Mouse   405 LLQSQGSQAGGSQTLKRDKEKK 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	252/368 (68%)
		CDC_Septin	43..311	CDD:206649	186/267 (70%)
		BAR	<252..405	CDD:299863	97/157 (62%)
Septin6	NP_001170795.1	CDC3	21..373	CDD:227352	245/351 (70%)
		CDC_Septin	39..307	CDD:206649	186/267 (70%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	49..56		5/6 (83%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	101..104		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	184..187		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..434		9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	432	1.000	Domainoid score	I577
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	592	1.000	Inparanoid score	I973
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51948
OrthoDB	1	1.010	-	-		D294076at33208
OrthoFinder	1	1.000	-	-		FOG0000793
OrthoInspector	1	1.000	-	-		mtm8814
orthoMCL	1	0.900	-	-		OOG6_101834
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X467
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840