DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sep5 and sept10

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001017557.1	Gene:	sept10 / 550129	ZFINID:	ZDB-GENE-050417-3	Length:	429	Species:	Danio rerio

Alignment Length:	410	Identity:	265/410 - (64%)
Similarity:	323/410 - (78%)	Gaps:	4/410 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KVPRLLQLGGHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTSFGSTPSPHNL 80
            |..|.|.|.||||||:|||||||||...||.|||||||||.:||||||||||||:|.:..|.|..
Zfish    12 KNARPLALSGHVGFDSLPDQLVNKSTSQGFCFNILCIGETGIGKSTLMDTLFNTNFENFESSHFE 76

  Fly    81 PNVKLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEELKIQRAMA 145
            |.|||:|.||:||||||||||||.:|:|:|||:||.:||:.:|:|:|:|||:||||||||:|::.
Zfish    77 PKVKLRAQTYDLQESNVRLKLTVVNTVGFGDQMNKQESYQHIVDYIDTQFESYLQEELKIKRSLH 141

  Fly   146 SAHDGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKERIMDELR 210
            :.||.|:|||||||.|:||.||::|||.||:||::||||||||||||||||||..||.:||.||.
Zfish   142 NYHDSRIHACLYFIAPSGHSLKSLDLVTMKKLDSKVNIIPVIAKADTISKSELHKFKIKIMSELV 206

  Fly   211 RNNVSIYQFPMDDETVSETNAAMNGHLPFAVVGSTEFVKVAGKQVRARQYPWGAVHIENEAHCDF 275
            .|.|.|||||:|||||::.|.|||||||||||||||.|.:..|.|:|||||||.|.:|||.||||
Zfish   207 SNGVQIYQFPIDDETVAKINTAMNGHLPFAVVGSTEEVNIGNKMVKARQYPWGVVQVENENHCDF 271

  Fly   276 VKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNNQPVSFQQTFESKRSDHLACLQ 340
            ||||||||..||||||||||||||||:|:.:|::|||.|.|...:|||.|||:|:||.:.|..||
Zfish   272 VKLREMLICVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPECKPVSLQQTYEAKRQEFLGELQ 336

  Fly   341 AKEEEVRQMFVQRVKQKENELKDNEKELHTKFDRLKREHLEEKAQLEEARRQLEEDCQELQRRR- 404
            .:|||:||.||||||:||.||||.|:||..||::|||.|.:||::|||.||.|||:.....:|:
Zfish   337 RREEEMRQTFVQRVKEKEAELKDAERELQGKFEQLKRLHADEKSKLEEKRRSLEEEMSVFSKRKA 401

  Fly   405 ---LQMANGSHTLTLGRGKK 421
               |..|...:|.|..:..|
Zfish   402 ATELLQAQSFNTSTNNKKDK 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	252/368 (68%)
		CDC_Septin	43..311	CDD:206649	187/267 (70%)
		BAR	<252..405	CDD:299863	97/156 (62%)
sept10	NP_001017557.1	CDC3	20..404	CDD:227352	256/383 (67%)
		CDC_Septin	39..307	CDD:206649	187/267 (70%)
		ATP-synt_B	<324..>410	CDD:304375	45/85 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576277
Domainoid	1	1.000	431	1.000	Domainoid score	I566
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	585	1.000	Inparanoid score	I964
OMA	1	1.010	-	-		QHG51948
OrthoDB	1	1.010	-	-		D294076at33208
OrthoFinder	1	1.000	-	-		FOG0000793
OrthoInspector	1	1.000	-	-		mtm6579
orthoMCL	1	0.900	-	-		OOG6_101834
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910