Protein Alignment Septin5 and septin5.2

DIOPT Version :10

• Sequence 1: NP_651961.1
• Gene: Septin5 / 43990
• FlyBaseID: FBgn0026361
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_001017039.1
• Gene: septin5.2 / 549793
• XenbaseID: XB-GENE-29208890
• Length: 350
• Species: Xenopus tropicalis
• Alignment Length: 352
• Identity: 148/352 - (42%)
• Similarity: 215/352 - (61%)
• Gaps: 37/352 - (10%)

  Fly    25 GHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTSFGSTPSPHNLP-------- 81
            |:|||..||:|:..|||:.||.|.::.:||:.||||||:::||.|..  .|..: :|
 Frog    15 GYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTDL--YPERY-IPGAAEKIER 76

  Fly    82 NVKLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEELKIQRAMAS 146
            .|:::|:|.|::|..|:|:|||.||.||||.:|..|.:|.::.|:|:|||.||.:|..:.|
 Frog    77 TVQIEASTVEIEERGVKLRLTVVDTPGYGDAINSQDCFKTIIHYIDNQFERYLHDESGLNR---- 137

  Fly   147 AH--DGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKERIMDEL 209
            .|  |.|||.|.|||.|.|||||.:|:..||.|..:|||:||||||||::..|....|.|::||:
 Frog   138 RHIIDNRVHCCFYFISPFGHGLKPLDVEFMKALHGKVNIVPVIAKADTLTLKERDRLKRRVLDEI 202

  Fly   210 RRNNVSIYQFP----MDDETVSETNAAMNGHLPFAVVGSTEFVKVAGKQVRARQYPWGAVHIENE 270
            ..:.:.|||.|    .:||...|....:...:||||:||.:.::|.||::|.|.||||.|.:||.
 Frog   203 AEHGIRIYQLPDADSDEDEEFKEQTRVLKASIPFAVIGSNQLIEVKGKKIRGRLYPWGVVEVENP 267

  Fly   271 AHCDFVKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNNQPVSFQQTFESKRSDH 335
            .|.||:|||.||: |:|:||:|.|...|||.||..||::.|        :||      |.:..|.
 Frog   268 EHNDFLKLRTMLV-THMQDLQEVTQDLHYENFRSERLKRTG--------KPV------EEEVLDK 317

  Fly   336 LACLQAKEEEVRQMFVQRVKQKENELK 362
            ...||.||.|:|:| .:.:.|.:.:::
 Frog   318 DMILQQKEAELRRM-QEMIAQMQAQMR 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Septin5	NP_651961.1	CDC_Septin	43..311	CDD:206649	125/281 (44%)
		COG4913	<274..>416	CDD:443941	33/89 (37%)
septin5.2	NP_001017039.1	Septin	34..305	CDD:395596	125/278 (45%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	43..50		4/6 (67%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	100..103		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	181..184		2/2 (100%)
		Important for dimerization. /evidence=ECO:0000250	259..269		5/9 (56%)