DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep5 and sept7a

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_021323700.1	Gene:	sept7a / 394136	ZFINID:	ZDB-GENE-040426-1008	Length:	443	Species:	Danio rerio

Alignment Length:	440	Identity:	178/440 - (40%)
Similarity:	273/440 - (62%)	Gaps:	24/440 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VTEKKTQEVATKVPRLL----QLGGHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDT 65
            :.|:...|.|..|.|::    .|.|:|||..||:|:..|||:.||.|.::.:||:.||||||:::
Zfish     3 IGERSVTEAAGSVNRMVAQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINS 67

  Fly    66 LFNTSFGST--PSP-HNL-PNVKLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYV 126
            ||.|...|:  |.| |.: ..|:::.:...::|..|:|.||:.||.|:||.|:.::.::.:::::
Zfish    68 LFLTDLYSSEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDHI 132

  Fly   127 DSQFEAYLQEELKIQRAMASAHDGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKAD 191
            ||:||.||..|.::.|....  |.|||.|||||.|:|||||.:|:..||:|..:|||||:|||||
Zfish   133 DSKFEDYLNAESRVNRRQMP--DSRVHCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKAD 195

  Fly   192 TISKSELSGFKERIMDELRRNNVSIYQFP-MDDETVSETNAAMNGHLPFAVVGSTEFVKVAGKQV 255
            |::..|...||::||.|::.:.:.||:|| .|||..|:....:...||.|||||...::|.||:|
Zfish   196 TLTPEECQQFKKQIMREIQEHKIKIYEFPETDDEEESKLVKKIKDRLPLAVVGSNTIIEVNGKRV 260

  Fly   256 RARQYPWGAVHIENEAHCDFVKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNN- 319
            |.||||||...:||..||||..||.|||||:|:||::.|:..|||.:|.|:|..:.:..||:|.
Zfish   261 RGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKN 325

  Fly   320 ----------QPVSFQQTFESKRSDHLACLQAKEEEVRQMFVQRVKQKENELKDNEKELHTKFDR 374
                      :.:|.....|.:|.||:|.::..|.|:.|:|..:||:|..:|||:|.||..:.::
Zfish   326 KGQLTKPDTVEGMSPLAQMEEERRDHVAKMKKMEMEMEQVFEMKVKEKIQKLKDSEGELQRRHEQ 390

  Fly   375 LKREHLEEKAQLEEARRQLEED--CQELQRRRLQMANGSHTLTLGRGKKK 422
            :|:....:..:|||.|||.||:  ..:.|:|.|:......:.||.:.|||
Zfish   391 MKKNLEAQHKELEEKRRQFEEEKASWDAQQRILEQQKLDASRTLEKNKKK 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	162/384 (42%)
		CDC_Septin	43..311	CDD:206649	123/272 (45%)
		BAR	<252..405	CDD:299863	66/165 (40%)
sept7a	XP_021323700.1	CDC_Septin	45..315	CDD:206649	123/271 (45%)
sept7a	XP_021323700.1	DUF3552	366..>440	CDD:330423	25/73 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820