Protein Alignment Septin5 and Septin12

DIOPT Version :10

• Sequence 1: NP_651961.1
• Gene: Septin5 / 43990
• FlyBaseID: FBgn0026361
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_001094335.1
• Gene: Septin12 / 363542
• RGDID: 1565511
• Length: 356
• Species: Rattus norvegicus
• Alignment Length: 359
• Identity: 127/359 - (35%)
• Similarity: 213/359 - (59%)
• Gaps: 41/359 - (11%)

  Fly    22 QLGGHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTSFGSTPSPH-NLP---N 82
            ::.|.||.:.:.|||..|:::.||.|||:.:|::.|||||:::|||.:....:|:|: ::|   .
  Rat    23 EMFGPVGIEAVLDQLRIKAMKTGFEFNIMVVGQSGLGKSTMVNTLFKSKVWQSPAPNLDVPMPQT 87

  Fly    83 VKLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEELKIQRAMASA 147
            ::|.:.|:.::|..::|||||.||.|:|||:|....:..::.|::.|:|.||||||.|.|   ..
  Rat    88 LELHSVTHVIEEKGLKLKLTVTDTPGFGDQINNDKCWDPILSYINQQYEQYLQEELLITR---QR 149

  Fly   148 H--DGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKERIMDELR 210
            |  |.|||.|:||:.||||.|:.:|:..:::|...||::||||:||:::..|...|:.||...|:
  Rat   150 HIPDTRVHCCVYFVPPTGHCLRPLDIEFLRRLCRTVNVVPVIARADSLTIEERDAFRSRIQQNLK 214

  Fly   211 RNNVSIYQFPMDDETVSE--TNAAMNGHLPFAVVGSTEFVKVAGKQVRARQYPWGAVHIENEAHC 273
            .:.:.:|.....||.:::  .|:.:...:||||||:.....|.|:.|..|:..||.:.:||.|||
  Rat   215 NHCIDVYPQQCFDEDINDRLLNSKIREQIPFAVVGADREHIVNGRCVLGRKTKWGIIEVENMAHC 279

  Fly   274 DFVKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQM-------GFVDVDSNNQPVSFQQTFESK 331
            :|:.||::|||::::||::.||..|||.:|..||.:.       |:|    |..|.|..|
  Rat   280 EFLLLRDLLIRSHLQDLKDITHNVHYENYRVLRLNESHVLPRGPGWV----NLAPASPGQ----- 335

  Fly   332 RSDHLACLQAKEEEVRQMFVQRVKQKENELKDNE 365
                   |.|...|       :|:::..:.:|:|
  Rat   336 -------LMAPGPE-------KVRKRSKDPRDDE 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Septin5	NP_651961.1	CDC_Septin	43..311	CDD:206649	108/282 (38%)
		COG4913	<274..>416	CDD:443941	28/99 (28%)
Septin12	NP_001094335.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		127/359 (35%)
		Interaction with SEPTIN7. /evidence=ECO:0000250|UniProtKB:Q8IYM1	44..317		108/275 (39%)
		CDC_Septin	45..315	CDD:206649	108/272 (40%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	54..61		3/6 (50%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	110..113		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	192..195		1/2 (50%)
		Self-association (via N-terminus) to polymerize octameric septin 12-7-6-2/4-2/4-6-7-12 filaments. /evidence=ECO:0000250|UniProtKB:Q8IYM1	256..356		39/123 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..356		9/45 (20%)