DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep5 and SEPTIN14

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_997249.2	Gene:	SEPTIN14 / 346288	HGNCID:	33280	Length:	432	Species:	Homo sapiens

Alignment Length:	398	Identity:	226/398 - (56%)
Similarity:	300/398 - (75%)	Gaps:	11/398 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KKTQEVATKVP-----------RLLQLGGHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKST 61
            ::|..:.|::|           |.|...||.||:.||:|||::|::.||:|||||:|||.:||||
Human     3 ERTMAMPTQIPADGDTQKENNIRCLTTIGHFGFECLPNQLVSRSIRQGFTFNILCVGETGIGKST 67

  Fly    62 LMDTLFNTSFGSTPSPHNLPNVKLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYV 126
            |:||||||:.....|.|...||.|:..|||||||||:|||||.:|:|||||::|..||:.:|:|:
Human    68 LIDTLFNTNLKDNKSSHFYSNVGLQIQTYELQESNVQLKLTVVETVGYGDQIDKEASYQPIVDYI 132

  Fly   127 DSQFEAYLQEELKIQRAMASAHDGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKAD 191
            |:||||||||||||:|::...||.|||.|||||.||||.||::||:.||.||::|||||:|||||
Human   133 DAQFEAYLQEELKIKRSLFEYHDSRVHVCLYFISPTGHSLKSLDLLTMKNLDSKVNIIPLIAKAD 197

  Fly   192 TISKSELSGFKERIMDELRRNNVSIYQFPMDDETVSETNAAMNGHLPFAVVGSTEFVKVAGKQVR 256
            ||||::|..||.:||.||..|.:.|||.|.|:||.::.|::::|.|||||||||:.|||..:.||
Human   198 TISKNDLQTFKNKIMSELISNGIQIYQLPTDEETAAQANSSVSGLLPFAVVGSTDEVKVGKRMVR 262

  Fly   257 ARQYPWGAVHIENEAHCDFVKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNNQP 321
            .|.||||.:.:|||.||||||||:||:.||||:|:|:|||:|||.:|.::||:|||.||..||||
Human   263 GRHYPWGVLQVENENHCDFVKLRDMLLCTNMENLKEKTHTQHYECYRYQKLQKMGFTDVGPNNQP 327

  Fly   322 VSFQQTFESKRSDHLACLQAKEEEVRQMFVQRVKQKENELKDNEKELHTKFDRLKREHLEEKAQL 386
            ||||:.||:||.:.....|.:|||::|.|:||||:||...|:.||||..||:.||....||..:|
Human   328 VSFQEIFEAKRQEFYDQCQREEEELKQRFMQRVKEKEATFKEAEKELQDKFEHLKMIQQEEIRKL 392

  Fly   387 EEARRQLE 394
            ||.::|||
Human   393 EEEKKQLE 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	219/368 (60%)
		CDC_Septin	43..311	CDD:206649	165/267 (62%)
		BAR	<252..405	CDD:299863	81/143 (57%)
SEPTIN14	NP_997249.2	CDC3	34..403	CDD:227352	219/367 (60%)
		CDC_Septin	49..317	CDD:206649	165/267 (62%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	59..66		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	111..114		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	194..197		2/2 (100%)
		DUF342	<328..403	CDD:302792	37/73 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51948
OrthoDB	1	1.010	-	-		D294076at33208
OrthoFinder	1	1.000	-	-		FOG0000793
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101834
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X467
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.790