DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep5 and sept8a

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001108589.1	Gene:	sept8a / 321590	ZFINID:	ZDB-GENE-030131-309	Length:	420	Species:	Danio rerio

Alignment Length:	404	Identity:	256/404 - (63%)
Similarity:	319/404 - (78%)	Gaps:	4/404 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RLLQLGGHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTSFGSTPSPHNLPNV 83
            |.|.||||||||:||||||:|||..||.|||||:|||.:||||||:|||||.|.:..:.|....|
Zfish    15 RNLSLGGHVGFDSLPDQLVSKSVTQGFCFNILCVGETGIGKSTLMNTLFNTMFENEEASHYQNGV 79

  Fly    84 KLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEELKIQRAMASAH 148
            .|:..||:||||||.||||:.||:|:|||:||.:|||.:|:|:|:|||.|||||||::|::.:.|
Zfish    80 YLRPRTYDLQESNVHLKLTIVDTVGFGDQINKEESYKPIVDYIDTQFENYLQEELKVKRSLFNYH 144

  Fly   149 DGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKERIMDELRRNN 213
            |.|:|.|||||.||||.||::|||.||:||::|||||:||||||||||||..||.:||.||..|.
Zfish   145 DTRIHICLYFISPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMSELVSNG 209

  Fly   214 VSIYQFPMDDETVSETNAAMNGHLPFAVVGSTEFVKVAGKQVRARQYPWGAVHIENEAHCDFVKL 278
            |.|||||.|||.|:|.|::||.|||||||||.|.|||..|.|||||||||.|.:|||:|||||||
Zfish   210 VQIYQFPTDDEAVTEINSSMNAHLPFAVVGSVEEVKVGNKTVRARQYPWGVVQVENESHCDFVKL 274

  Fly   279 REMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNNQPVSFQQTFESKRSDHLACLQAKE 343
            ||||||.||||||||||.|||||:|:.:|::|||.|.|.::||.|.|:|:|:||.:.|..||.||
Zfish   275 REMLIRVNMEDLREQTHARHYELYRRCKLEEMGFKDTDPDSQPFSLQETYEAKRKEFLGDLQKKE 339

  Fly   344 EEVRQMFVQRVKQKENELKDNEKELHTKFDRLKREHLEEKAQLEEARRQLEEDCQELQRRRLQMA 408
            ||:|||||.:||:.|.|||:.|:|||.||::|||.|.|||.::||.||:|||:.....||::
Zfish   340 EEMRQMFVNKVKETEAELKEKERELHEKFEQLKRMHQEEKRKVEEKRRELEEEMNAFNRRKV--- 401

  Fly   409 NGSHTLTLGRGKKK 422
             .:.||:|.:..||
Zfish   402 -AAETLSLSQPLKK 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	242/368 (66%)
		CDC_Septin	43..311	CDD:206649	179/267 (67%)
		BAR	<252..405	CDD:299863	97/152 (64%)
sept8a	NP_001108589.1	CDC3	21..382	CDD:227352	238/360 (66%)
		CDC_Septin	39..307	CDD:206649	179/267 (67%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	49..56		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	101..104		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	184..187		2/2 (100%)
		Syntaphilin	<330..>377	CDD:291936	28/46 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..420		7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	431	1.000	Domainoid score	I566
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	585	1.000	Inparanoid score	I964
OMA	1	1.010	-	-		QHG51948
OrthoDB	1	1.010	-	-		D294076at33208
OrthoFinder	1	1.000	-	-		FOG0000793
OrthoInspector	1	1.000	-	-		mtm6579
orthoMCL	1	0.900	-	-		OOG6_101834
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840