DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep5 and SEPTIN6

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_011529619.1	Gene:	SEPTIN6 / 23157	HGNCID:	15848	Length:	526	Species:	Homo sapiens

Alignment Length:	412	Identity:	262/412 - (63%)
Similarity:	326/412 - (79%)	Gaps:	9/412 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RLLQLGGHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTSFGSTPSPHNLPNV 83
            |.:.|.||||||:||||||||||..||.|||||:|||.|||||||||||||.|...|:.|..|.|
Human    15 RTVPLAGHVGFDSLPDQLVNKSVSQGFCFNILCVGETGLGKSTLMDTLFNTKFEGEPATHTQPGV 79

  Fly    84 KLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEELKIQRAMASAH 148
            :|::|||:|||||||||||:..|:|:|||:||.||||.:||::|:||||||||||||:|.:.:.|
Human    80 QLQSNTYDLQESNVRLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHTYH 144

  Fly   149 DGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKERIMDELRRNN 213
            |.|:|.|||||.||||.||::|||.||:||::|||||:|||||.||||||:.||.:|..||..|.
Human   145 DSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADAISKSELTKFKIKITSELVSNG 209

  Fly   214 VSIYQFPMDDETVSETNAAMNGHLPFAVVGSTEFVKVAGKQVRARQYPWGAVHIENEAHCDFVKL 278
            |.|||||.|||:|:|.|..||.||||||:||||.:|:..|.:||||||||.|.:|||||||||||
Human   210 VQIYQFPTDDESVAEINGTMNAHLPFAVIGSTEELKIGNKMMRARQYPWGTVQVENEAHCDFVKL 274

  Fly   279 REMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNNQPVSFQQTFESKRSDHLACLQAKE 343
            ||||||.||||||||||||||||:|:.:|::|||.|.|.:::|.|.|:|:|:||::.|..||.||
Human   275 REMLIRVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGELQKKE 339

  Fly   344 EEVRQMFVQRVKQKENELKDNEKELHTKFDRLKREHLEEKAQLEEARRQLEEDCQELQRRR---- 404
            ||:|||||||||:||.|||:.|||||.||||||:.|.:||.:||:.::.|:::....::|:
Human   340 EEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQDEKKKLEDKKKSLDDEVNAFKQRKTAAE 404

  Fly   405 -LQ----MANGSHTLTLGRGKK 421
             ||    .|.||.||...:.||
Human   405 LLQSQGSQAGGSQTLKRDKEKK 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	249/368 (68%)
		CDC_Septin	43..311	CDD:206649	184/267 (69%)
		BAR	<252..405	CDD:299863	96/157 (61%)
SEPTIN6	XP_011529619.1	CDC3	21..373	CDD:227352	243/351 (69%)
SEPTIN6	XP_011529619.1	CDC_Septin	39..307	CDD:206649	184/267 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	432	1.000	Domainoid score	I589
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	591	1.000	Inparanoid score	I986
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51948
OrthoDB	1	1.010	-	-		D294076at33208
OrthoFinder	1	1.000	-	-		FOG0000793
OrthoInspector	1	1.000	-	-		mtm8585
orthoMCL	1	0.900	-	-		OOG6_101834
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840