DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep5 and Septin4

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_006532556.1	Gene:	Septin4 / 18952	MGIID:	1270156	Length:	971	Species:	Mus musculus

Alignment Length:	366	Identity:	143/366 - (39%)
Similarity:	218/366 - (59%)	Gaps:	23/366 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 HVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTS-------FGSTPSPHNLPNV 83
            :|||.|||:|:..|||:.||.|.::..||:.||||||:::||.|.       .|:  ....:..|
Mouse   617 YVGFATLPNQVHRKSVKKGFDFTLMVAGESGLGKSTLVNSLFLTDLYRDRKLLGA--EERIMQTV 679

  Fly    84 KLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEELKIQRAMASAH 148
            ::..:..:::|..|||:||:.||.|:||.||..:.:|.:.||:|.|||.|.::|..:.|  .:..
Mouse   680 EITKHAVDIEEKGVRLRLTIVDTPGFGDAVNNTECWKPVAEYIDQQFEQYFRDESGLNR--KNIQ 742

  Fly   149 DGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKERIMDELRRNN 213
            |.|||.|||||.|.||||:.:|:..||.|..||||:|::|||||::..|:...|.:|.:|:....
Mouse   743 DNRVHCCLYFISPFGHGLRPLDVEFMKALHQRVNIVPILAKADTLTPPEVDRKKCKIREEIEHFG 807

  Fly   214 VSIYQFP----MDDETVSETNAAMNGHLPFAVVGSTEFVKVAGKQVRARQYPWGAVHIENEAHCD 274
            :.|||||    .:||.....:.|:...:||||:||...|:..|::||.|.||||.|.:||..|||
Mouse   808 IKIYQFPDCDSDEDEDFKLQDQALKESIPFAVIGSNTVVEARGRRVRGRLYPWGIVEVENPGHCD 872

  Fly   275 FVKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNNQPVSFQQTFESKRSDHL-AC 338
            |||||.||:||:|:||::.|...|||.:|.:.:|.|..:.|...|:.   :.|.||.....: |.
Mouse   873 FVKLRTMLVRTHMQDLKDVTRETHYENYRAQCIQSMTRLVVKERNRN---KLTRESGTDFPIPAV 934

  Fly   339 LQAKEEEVRQMFVQRVKQKENELKDNEKELHTKFDRLKREH 379
            ....:.|..::    :::|:.||:..::.||....::|..|
Mouse   935 PPGTDPETEKL----IREKDEELRRMQEMLHKIQRQMKETH 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	143/366 (39%)
		CDC_Septin	43..311	CDD:206649	118/278 (42%)
		BAR	<252..405	CDD:299863	47/129 (36%)
Septin4	XP_006532556.1	DUF4655	14..509	CDD:373934
Septin4	XP_006532556.1	Septin	634..914	CDD:366275	119/283 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820