Protein Alignment Septin5 and SEPTIN1

DIOPT Version :10

• Sequence 1: NP_651961.1
• Gene: Septin5 / 43990
• FlyBaseID: FBgn0026361
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_443070.6
• Gene: SEPTIN1 / 1731
• HGNCID: 2879
• Length: 372
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 144/390 - (36%)
• Similarity: 219/390 - (56%)
• Gaps: 51/390 - (13%)

  Fly    26 HVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTSF---GSTP--SPHNLPNVKL 85
            :|||..||:||..|||:.||.|.::..||:.||||||:::||.|:.   ...|  |......:.:
Human    10 YVGFAALPNQLHRKSVKKGFDFTLMVAGESGLGKSTLINSLFLTNLYEDRQVPEASARLTQTLAI 74

  Fly    86 KANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEELKIQRAMASAHDG 150
            :....|::|..|::|||:.||.|:||.|:.:|.:..:|::::.|||.||::|..:.|  .:..|.
Human    75 ERRGVEIEEGGVKVKLTLVDTPGFGDSVDCSDCWLPVVKFIEEQFEQYLRDESGLNR--KNIQDS 137

  Fly   151 RVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKERIMDELRRNNVS 215
            |||.|||||.|.|.||:.:|:..::.:..:|||||||.|||.:...|....|::|.|:|:...:.
Human   138 RVHCCLYFISPFGRGLRPLDVAFLRAVHEKVNIIPVIGKADALMPQETQALKQKIRDQLKEEEIH 202

  Fly   216 IYQFPM----DDETVSETNAAMNGHLPFAVVGSTEFVKVAG-KQVRARQYPWGAVHIENEAHCDF 275
            |||||.    :||.....:|.|...:|||||||.|.|:..| :.||.|:|.||.|.:||..||||
Human   203 IYQFPECDSDEDEDFKRQDAEMKESIPFAVVGSCEVVRDGGNRPVRGRRYSWGTVEVENPHHCDF 267

  Fly   276 VKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNNQPVSFQQTFESKRSDHLACLQ 340
            :.||.||::|:::||:|.||...||.:|.|.||.:.        :|.:..:...||.|
Human   268 LNLRRMLVQTHLQDLKEVTHDLLYEGYRARCLQSLA--------RPGARDRASRSKLS------- 317

  Fly   341 AKEEEVRQMFVQRVKQKENE-------LKDNEKELHTKFDRLKR--EHLEE-KAQLEEARRQLEE 395
                          :|...|       |.|.||.:..|.:.|:|  |.||: :||:::::.|.|:
Human   318 --------------RQSATEIPLPMLPLADTEKLIREKDEELRRMQEMLEKMQAQMQQSQAQGEQ 368

  Fly   396  395
            Human   369  368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Septin5	NP_651961.1	CDC_Septin	43..311	CDD:206649	114/277 (41%)
		COG4913	<274..>416	CDD:443941	38/132 (29%)
SEPTIN1	NP_443070.6	Septin	28..301	CDD:395596	113/274 (41%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	37..44		4/6 (67%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	94..97		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	175..178		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	352..372		6/17 (35%)