DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep5 and SEPTIN9

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001106963.1	Gene:	SEPTIN9 / 10801	HGNCID:	7323	Length:	586	Species:	Homo sapiens

Alignment Length:	295	Identity:	120/295 - (40%)
Similarity:	192/295 - (65%)	Gaps:	14/295 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTSFG----STPSPHNLP-NVK 84
            |:||.|::.:|:..|:::.||.|||:.:|::.||||||::|||.:...    ...|...:| .::
Human   277 GYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIE 341

  Fly    85 LKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEELKIQRAMASAHD 149
            :|:.|::::|..||:||||.||.|:||.:|..:.::.::::::.|:|.|||||:.|.| .....|
Human   342 IKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINR-KKRIPD 405

  Fly   150 GRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKERIMDELRRNNV 214
            .|||.|||||..|||.|:.:|:..||:|...|||:||||||||::..|...||:||..:|..|.:
Human   406 TRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVHFKQRITADLLSNGI 470

  Fly   215 SIY---QFPMD--DETVSETNAAMNGHLPFAVVGSTEFVKVAGKQVRARQYPWGAVHIENEAHCD 274
            .:|   :|..|  |..|:|....|   :|||||||....:|.||::..|:..||.:.:||..||:
Human   471 DVYPQKEFDEDSEDRLVNEKFREM---IPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCE 532

  Fly   275 FVKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQ 309
            |..||::||||:|:::::.|.:.|:|.:|.:||.:
Human   533 FAYLRDLLIRTHMQNIKDITSSIHFEAYRVKRLNE 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	120/295 (41%)
		CDC_Septin	43..311	CDD:206649	114/277 (41%)
		BAR	<252..405	CDD:299863	23/58 (40%)
SEPTIN9	NP_001106963.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..268
		CDC3	277..583	CDD:227352	120/295 (41%)
		CDC_Septin	295..569	CDD:206649	114/277 (41%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	305..312		3/6 (50%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	362..365		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	444..447		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820