DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep5 and Septin10

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001365992.1	Gene:	Septin10 / 103080	MGIID:	1918110	Length:	456	Species:	Mus musculus

Alignment Length:	423	Identity:	249/423 - (58%)
Similarity:	324/423 - (76%)	Gaps:	10/423 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KTQEVATKVPRLLQLGGHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTSFGS 73
            :.|::..:.||.|.:.|||||::||||||::|::.||.|||||:|||.:|||||::|||||:|..
Mouse     6 EVQQLIKEHPRSLSMCGHVGFESLPDQLVDRSIEQGFCFNILCVGETGIGKSTLINTLFNTNFEE 70

  Fly    74 TPSPHNLPNVKLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEEL 138
            ..|.|..|.|:|:|.||||||||||||||:.:|:|:|||:||.|||:.:|:|:|.||||||||||
Mouse    71 LESSHFCPCVRLRAQTYELQESNVRLKLTIVNTVGFGDQINKEDSYQPIVDYIDDQFEAYLQEEL 135

  Fly   139 KIQRAMASAHDGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKE 203
            ||:||:.:.||.|:|.|||||.||||.|:.:||:.||.||.:|||||:||||||||||||..||.
Mouse   136 KIKRALFNYHDSRIHVCLYFIAPTGHSLRTLDLLTMKSLDNKVNIIPLIAKADTISKSELQKFKM 200

  Fly   204 RIMDELRRNNVSIYQFPMDDETVSETNAAMNGHLPFAVVGSTEFVKVAGKQVRARQYPWGAVHIE 268
            ::|:||..|.|.|||||.||:|.|:.|.|||||||||||||.:.:||..|.|:.||||||.|.:|
Mouse   201 KLMNELVINGVQIYQFPTDDDTTSKINGAMNGHLPFAVVGSMDEIKVGNKMVKGRQYPWGIVQVE 265

  Fly   269 NEAHCDFVKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNNQPVSFQQTFESKRS 333
            ||.||||||||||||.|||||||||||.|||||:|:.:||:|||||:...|:|:|.|:|:|:||.
Mouse   266 NENHCDFVKLREMLICTNMEDLREQTHMRHYELYRRCKLQEMGFVDMGPENKPLSLQETYEAKRH 330

  Fly   334 DHLACLQAKEEEVRQMFVQRVKQKENELKDNEKELHTKFDRLKREHLEEKAQLEEARRQLEEDCQ 398
            :.....|.|||:::||||||||:||..||:.|:||..||:.|||.|.||:.:|||.||.|||:..
Mouse   331 EFYGERQRKEEQMKQMFVQRVKEKEAILKEAERELQAKFEHLKRIHQEERMKLEEKRRMLEEESV 395

  Fly   399 ELQRRRLQ---------MANGSHTLTLGRGKKK 422
            ...:::..         :|:|| ::...:.:||
Mouse   396 AFAKKKATCELFPNQSFLASGS-SIRKDKDRKK 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	237/368 (64%)
		CDC_Septin	43..311	CDD:206649	180/267 (67%)
		BAR	<252..405	CDD:299863	91/152 (60%)
Septin10	NP_001365992.1	CDC_Septin	40..308	CDD:206649	180/267 (67%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	50..57		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	102..105		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	185..188		2/2 (100%)
		PTZ00121	<274..426	CDD:173412	77/152 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833559
Domainoid	1	1.000	432	1.000	Domainoid score	I577
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	592	1.000	Inparanoid score	I973
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51948
OrthoDB	1	1.010	-	-		D294076at33208
OrthoFinder	1	1.000	-	-		FOG0000793
OrthoInspector	1	1.000	-	-		mtm8814
orthoMCL	1	0.900	-	-		OOG6_101834
Panther	1	1.100	-	-	O	PTHR18884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X467
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770