DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sep5 and septin2

DIOPT Version :9

Sequence 1:	NP_651961.1	Gene:	Sep5 / 43990	FlyBaseID:	FBgn0026361	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001090723.1	Gene:	septin2 / 100036706	XenbaseID:	XB-GENE-480201	Length:	355	Species:	Xenopus tropicalis

Alignment Length:	338	Identity:	147/338 - (43%)
Similarity:	203/338 - (60%)	Gaps:	33/338 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GHVGFDTLPDQLVNKSVQNGFSFNILCIGETALGKSTLMDTLFNTSF-------GSTPSPHNLPN 82
            |:|||..||:|:..|||:.||.|.::.:||:.||||||:::||.|..       |:......  .
Frog    15 GYVGFANLPNQVHRKSVRKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERVVPGAADKIER--T 77

  Fly    83 VKLKANTYELQESNVRLKLTVCDTIGYGDQVNKADSYKALVEYVDSQFEAYLQEELKIQRAMASA 147
            |:::|:|.|::|..|:|:|||.||.||||.:|..|.:|.::.|||:|||.||.:|..:.|    .
Frog    78 VEIEASTVEIEERGVKLRLTVVDTPGYGDAMNCVDCFKPIISYVDNQFERYLHDESGLNR----R 138

  Fly   148 H--DGRVHACLYFICPTGHGLKAMDLVCMKQLDTRVNIIPVIAKADTISKSELSGFKERIMDELR 210
            |  |.|||.|.|||.|.|||||.:|:..||.|..:|||:||||||||::..|....|.|::||:.
Frog   139 HIVDNRVHCCFYFISPFGHGLKPLDVEFMKALHNKVNIVPVIAKADTLTLRERERLKRRVLDEIE 203

  Fly   211 RNNVSIYQFP----MDDETVSETNAAMNGHLPFAVVGSTEFVKVAGKQVRARQYPWGAVHIENEA 271
            .:.:.|||.|    .:||...|....:...:||.||||.:.::..||:||.|.||||.|.:||..
Frog   204 EHGIKIYQLPDAESDEDEDFKEQTRLLKASIPFTVVGSNQLIEAKGKKVRGRLYPWGVVEVENPE 268

  Fly   272 HCDFVKLREMLIRTNMEDLREQTHTRHYELFRQRRLQQMGFVDVDSNNQPVSFQQTFESKRSDHL 336
            |.||:|||.||| |:|:||:|.|...|||.||..||::.....|:  |..|:..|
Frog   269 HNDFLKLRTMLI-THMQDLQEVTQDLHYENFRSERLKKGVASKVE--NVEVTKDQ---------- 320

  Fly   337 ACLQAKEEEVRQM 349
             .||.||.|:|:|
Frog   321 -ILQEKEAELRRM 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sep5	NP_651961.1	CDC3	25..394	CDD:227352	147/338 (43%)
		CDC_Septin	43..311	CDD:206649	126/280 (45%)
		BAR	<252..405	CDD:299863	45/98 (46%)
septin2	NP_001090723.1	Septin	33..313	CDD:366275	127/288 (44%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	43..50		4/6 (67%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	100..103		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01056	181..184		2/2 (100%)
		Important for dimerization. /evidence=ECO:0000250	259..269		5/9 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920