DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sdic1 and CG14838

DIOPT Version :9

Sequence 1:	NP_524670.2	Gene:	Sdic1 / 43984	FlyBaseID:	FBgn0067861	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	92/443 - (20%)
Similarity:	146/443 - (32%)	Gaps:	170/443 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NVQATNIPPKETLVYTKQTQTTSTGGGNG----------DVLAFDAQGDDEESSLQNLGNGFTSK 84
            ||...:.|||    ..::.||..|...|.          :.|..|....|||...:.      ::
  Fly   269 NVSVQSAPPK----IEREQQTNPTFPSNAWSQYLYEIDDEDLELDETDVDEEEEKKK------AQ 323

  Fly    85 LPPGYLTHGLPTVKDVAPAITPLEIKKETEV---KKEVNELSEEQKQMIILSENFQRFVVRAGRV 146
            ..||  |:       |.|...|.|:..:.|:   ..|.|::...:....::|
  Fly   324 AKPG--TY-------VEPEKKPPEMSAQIEMLLNTLEFNQIDSYRDDYSLIS------------- 366

  Fly   147 IERALSENVDIYTD-YIGGGDSEE----ANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFP 206
                 |..|..||: |:     :|    ||..:|:.|.                :...||.....
  Fly   367 -----SRQVVQYTNPYL-----QEFLCFANISKSNKRF----------------VAGYDWYPKLS 405

  Fly   207 ELVVGSYHNN-----EESPNEPDGV---------VMVW----NTKFKKSTPEDVFHCQSAVMSTC 253
            .|:..||..:     .|:.|..|.|         |::|    |..:|..     |.......:..
  Fly   406 GLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPVLLWSFSDNLNYKLE-----FEAPIETTALT 465

  Fly   254 FAKFNPNLILGGTYSGQIVLWD--NRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISIS 316
            |..||.:::|||:.:||:||||  .|.:|..  :...|:||...:.:    |:
  Fly   466 FCPFNGDILLGGSKNGQVVLWDLQGRCEKLD--EEEYLTAAQAKYRI----MI------------ 512

  Fly   317 SDGKLCSWSLDMLSQPQD------TLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASR 375
              |:..:|::|:    :|      |:.|.....|. |||:.                   |...|
  Fly   513 --GEFLNWTIDI----EDNVIVPATISLLDCSPKG-AITAF-------------------YWLGR 551

  Fly   376 HGLRSGVNEVYERHLGPITGISTHYNQLSPDFGH---LFLTSSIDWTIKLWSL 425
                    .:|....|.:      ||  .||..:   .|:|.:.|.||..|.|
  Fly   552 --------SIYLSQFGKV------YN--DPDIRNHHKFFVTCAFDGTISFWDL 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sdic1	NP_524670.2	Dynein_IC2	23..51	CDD:288403	6/20 (30%)
		NtpH	108..>178	CDD:225368	14/77 (18%)
		WD40	196..>445	CDD:295369	57/259 (22%)
		WD40	<196..442	CDD:225201	57/259 (22%)
		WD40 repeat	196..245	CDD:293791	14/66 (21%)
		WD40 repeat	251..289	CDD:293791	14/39 (36%)
		WD40 repeat	298..337	CDD:293791	6/44 (14%)
		WD40 repeat	349..386	CDD:293791	3/36 (8%)
		WD40 repeat	393..435	CDD:293791	11/36 (31%)
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	76/372 (20%)
		WD40 repeat	462..505	CDD:293791	16/44 (36%)
		WD40 repeat	510..547	CDD:293791	11/78 (14%)
		RE_R_Pab1	807..>863	CDD:286594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435265
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840