Protein Alignment Oamb and hrh2a

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_001038803.2
• Gene: hrh2a / 735303
• ZFINID: ZDB-GENE-070531-4
• Length: 369
• Species: Danio rerio
• Alignment Length: 611
• Identity: 138/611 - (22%)
• Similarity: 204/611 - (33%)
• Gaps: 292/611 - (47%)

  Fly    22 ISLAV-LEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKV 85
            |:||| |..:.:|.:.||.||..||:.:.:||:|||.|||:|||.|.|:|..|||||..::|...
Zfish     5 IALAVTLSVLILLTVSGNILVCLAVYATRRLRNVTNCFIVSLAVTDFLLGALVLPFSTLYQVTGD 69

  Fly    86 WIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFF 150
            |..|..:|.|::::||.:||||||||.|||||||.|||.|:.||.::...:..:::|.||::|..
Zfish    70 WPLGAHFCNIYISLDVMLCTASILNLFAISLDRYFAVTAPLRYPMLVLPWRVGAILATIWLVSVG 134

  Fly   151 ICFPPL-VGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNG 214
            :.|.|: :||..:...:| ...:|:|.                    :|
Zfish   135 VSFVPIHLGWNTRDLSVQ-NIREGDHA--------------------RD---------------- 162

  Fly   215 NAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTI 279
                                                                             
Zfish   163 ----------------------------------------------------------------- 162

  Fly   280 SGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYR-AAVRTTRAINQGFKTTKGSKGIG 343
                   |....:..|.:..|..:||:|:..|.:.|.|::| |.:|..|.|
Zfish   163 -------CRFELNPTYAIVDAFSTFYLPLLAMCWSYHRVFRIARMRAKRII-------------- 206

  Fly   344 SRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSY 408
                                                            :||
Zfish   207 ------------------------------------------------STR-------------- 209

  Fly   409 PSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGL 473
                                                |.||.||                    |:
Zfish   210 ------------------------------------RGSTSSQ--------------------GV 218

  Fly   474 PELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTM 538
            ..|..|                                  |.||..|||:::|.|:.||.|:||.
Zfish   219 TILTLR----------------------------------EHKATVTLAVVLGAFVVCWFPYFTF 249

  Fly   539 YIIRPFCQDCVDP-LLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSVSLKSS 602
            :.|.....:...| ...||:.||||.|||:||::||..::|||.|:.:::|            ..
Zfish   250 FTIMGIRNEENPPQTAQSVVLWLGYANSALNPVLYATLNRDFRSAYAKLLC------------GG 302

  Fly   603 RRGSDMSAIRIRARTPSITPSAAAHS 628
            ||....:.|.| |.|.:.|.:..|||
Zfish   303 RRCKTETTIPI-AATAAGTMTGHAHS 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	126/564 (22%)
		TM helix 1	22..48	CDD:320191	12/26 (46%)
		TM helix 2	55..81	CDD:320191	16/25 (64%)
		TM helix 3	93..123	CDD:320191	20/29 (69%)
		TM helix 4	135..158	CDD:320191	6/23 (26%)
		TM helix 5	292..321	CDD:320191	9/29 (31%)
		TM helix 6	512..542	CDD:320191	13/29 (45%)
		TM helix 7	551..576	CDD:320191	14/25 (56%)
hrh2a	NP_001038803.2	7tmA_Histamine_H2R	5..295	CDD:320179	126/564 (22%)
		TM helix 1	6..32	CDD:320179	11/25 (44%)
		TM helix 2	39..66	CDD:320179	16/26 (62%)
		TM helix 3	77..107	CDD:320179	20/29 (69%)
		TM helix 4	119..139	CDD:320179	5/19 (26%)
		TM helix 5	168..198	CDD:320179	9/29 (31%)
		TM helix 6	223..253	CDD:320179	14/63 (22%)
		TM helix 7	263..288	CDD:320179	13/24 (54%)