Protein Alignment Oamb and 5-HT2B

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: XP_061501050.1
• Gene: 5-HT2B / 5667641
• VectorBaseID: AGAMI1_004218
• Length: 908
• Species: Anopheles gambiae
• Alignment Length: 799
• Identity: 177/799 - (22%)
• Similarity: 278/799 - (34%)
• Gaps: 266/799 - (33%)

  Fly    32 VLVIG---GNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKVWIFGDLWC 93
            :||.|   ||.||..|:....:|::|||:|:::||:.||:|.|:|:|......|...:.....:|
Mosquito   123 ILVFGTAAGNILVCLAIVWERRLQNVTNYFLMSLAITDLMVALSVMPLGILTLVKGHFPLDSEYC 187

  Fly    94 RIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFICFP-PLV 157
            .:|:.:||..|||||::||.||:|||:::..|:.:....:.::....|:.:|:||..:..| .|:
Mosquito   188 LVWICLDVLFCTASIMHLCTISVDRYLSLRYPMKFGRNKTRRRVVLKISFVWLLSIAMSLPLSLM 252

  Fly   158 GWKDQKAVI--------QPTY-----------PKGNHTLYYTTTM----SSSED----------- 188
            ..|:..:|:        .|.|           |.....:.||.|:    ..||:
Mosquito   253 YSKNHASVLVDGTCQIPDPVYKLVGSIVCFYIPLCVMLITYTLTVRLLAQQSENLGGVGSGGGWS 317

  Fly   189 -GQLGLDSIKDQG-------EASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDS----- 240
             |.||.....|:.       :.|||.         |.||:    |....|.:..::.:|:
Mosquito   318 SGWLGQAPAFDRRNTWKRIIKLSLPA---------AQNPH----AHSAASTDTELSTLDNHDLWL 369

  Fly   241 --TSTSTTATTTTTA-----------------------------SSSSTTETEMDLDLLNAPPQN 274
              :|....::.|.||                             .||.:.|...:.:.....|.|
Mosquito   370 LESSIPEPSSITMTAMQRFGEEMLKLSQGLESVAQHSDRNSGQNGSSRSPEPSREKESFRKKPAN 434

  Fly   275 RPQ--------TISGSCPWKCELTNDRGYVLYSALGSFYIPMFVML------------------- 312
            ...        |:....|.|...::...::.....|:   |..|.|
Mosquito   435 AKHAPTPVTMVTVRSPVPSKKRRSSTSTWIARRNSGT---PPPVRLVRKRFKSLPHALPPPASDD 496

  Fly   313 ------FFYWRIYRAAVRTTRAINQGFKTTKGSKGI------GSRFEEQRLTLRIHRGRGSNQQD 365
                  |....:|....|..|....|.....|:.|:      .||....|   |..|..|||...
Mosquito   497 IEVDEQFMQDVLYELRDREDRGSVHGSSARPGAAGLDGVPAAASRATSDR---REGRDAGSNPAG 558

  Fly   366 --SMHSNGSTQSTTTTLGTPSPERLSKY-----ATRRLHHHDKIKI------------------- 404
              ..|...:...|..||..|.|.:...:     ..::.....:|||
Mosquito   559 PRQAHPLAAPSQTAATLKLPPPCKCPFFGEGAPGRQQYLRPAEIKIVKTSTDFGPMGGAASNGDS 623

  Fly   405 ----SVSYPSSENI-----------------SELAGHGDVG---------------HERRQS--G 431
                ::|..|..|:                 |.||.....|               |:||.|  |
Mosquito   624 LVYSTISISSGSNVTTQPTRSISSSLSTLPASALASPSRKGSAPKGISVVTWDQRRHQRRGSSFG 688

  Fly   432 NAL-------------------------FAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQ--- 468
            .|.                         .|:...|..|..|....::|...:...:|.|.:|
Mosquito   689 GARTSLLLTPTKASPSSVSLRRSINLRHSALEGGGGGGGGSAGETMFRGAPKKNSSSPCLMQHQT 753

  Fly   469 --------VGKG----------------LPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVK 509
                    ||.|                :|.||    .|:.|..|.|||  |..|..||.....:
Mosquito   754 GGGGGGGAVGGGNGTAVAMMAVAAASSTVPTLA----TTTMAVRSHHSR--NSSMISRNSSRHGR 812

  Fly   510 RFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQDC---VDPLLFSVLFWLGYCNSAVNPMI 571
            ..|:|.||.|.|.::...|:..|.|||.:.::...|:.|   :|..:|..:.||||.:|.|||:.
Mosquito   813 IIRLEQKATKVLGVVFFTFVILWAPFFVLNLLPSVCKHCEDNIDQWVFEFVTWLGYASSLVNPIF 877

  Fly   572 YALFSKDFRFAFKRI-ICR 589
            |.:|:|.||.||::: :||
Mosquito   878 YTIFNKAFRDAFRKVLLCR 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	173/790 (22%)
		TM helix 1	22..48	CDD:320191	8/18 (44%)
		TM helix 2	55..81	CDD:320191	11/25 (44%)
		TM helix 3	93..123	CDD:320191	16/29 (55%)
		TM helix 4	135..158	CDD:320191	6/23 (26%)
		TM helix 5	292..321	CDD:320191	6/53 (11%)
		TM helix 6	512..542	CDD:320191	11/29 (38%)
		TM helix 7	551..576	CDD:320191	10/24 (42%)
5-HT2B	XP_061501050.1	None