DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oamb and adra1ab

DIOPT Version :9

Sequence 1:	NP_001262774.1	Gene:	Oamb / 43982	FlyBaseID:	FBgn0024944	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_021334987.1	Gene:	adra1ab / 557259	ZFINID:	ZDB-GENE-060503-384	Length:	431	Species:	Danio rerio

Alignment Length:	692	Identity:	171/692 - (24%)
Similarity:	240/692 - (34%)	Gaps:	298/692 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EDLIKSVKWTEP-ANLISLAVLEF--INVLVIG------------GNCLVIAAVFCSNKLRSVTN 56
            ||.|.|..:.|. :|..::.|||.  ...||:|            ||.|||.:|.|...|||||:
Zfish     8 EDYINSTFFPENCSNCSTIPVLEIDVTKTLVLGLVLVLFLIFGVMGNILVILSVACHRNLRSVTH 72

  Fly    57 FFIVNLAVADLLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVA 121
            :||.|||:||||:...||||||..|....|:||...|..|.|:||..||||||:||.||:||.:|
Zfish    73 YFIGNLAIADLLLSSVVLPFSAVSEALGRWVFGRHLCNAWTALDVLCCTASILSLCVISVDRCMA 137

  Fly   122 VTRPVTYPSIMSTKKAKSLIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSS 186
            |:.|:.|||..:.::|.:.:|.:|.||..|...||.||::
Zfish   138 VSYPLQYPSFATGRRAMTAVAALWALSAAISVGPLFGWRE------------------------- 177

  Fly   187 EDGQLGLDSIKDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTT 251
                               |.|.                  |.|.
Zfish   178 -------------------PMPE------------------DESV-------------------- 185

  Fly   252 TASSSSTTETEMDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYW 316
                                               |.:..|.||.::||..|||:|:.|:|..|.
Zfish   186 -----------------------------------CRVNEDPGYAIFSAACSFYVPLAVILAMYC 215

  Fly   317 RIYRAAVRTTRAINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLG 381
            |:|..|...|||:::. :.|.|       ..||.:|||||..:..|.
Zfish   216 RVYVVARHKTRAMSKS-RETNG-------LSEQGMTLRIHCRKAQND------------------ 254

  Fly   382 TPSPERLSKYATRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRE 446
                       ||:   .|.:::.                          |:.||.
Zfish   255 -----------TRK---EDAMRLK--------------------------NSHFAF--------- 270

  Fly   447 STESQLYRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRF 511
                                                                       .::.:|
Zfish   271 -----------------------------------------------------------MRLLKF 276

  Fly   512 RMETKAAKTLAIIVGMFIFCWCPFFTMYII-------RPFCQDCVDPLLFSVLFWLGYCNSAVNP 569
            ..|.||||||.|:||.|:.||.|||.:..|       ||  .|.|    |.:.|||||.||.:||
Zfish   277 SREKKAAKTLGIVVGCFVLCWLPFFLVLPISSIFPSHRP--PDAV----FKITFWLGYFNSCLNP 335

  Fly   570 MIYALFSKDFRFAFKRII-CRCFCSRQSVSLKSSRRGSDMSAIRIRARTPSITPSAAAHSFGDES 633
            :||..||::|:.||:.:: .||      :|..........:|.:...::|....|....|:..:.
Zfish   336 IIYPCFSQEFKKAFQNVLHGRC------LSRTHQTWSPPANATQYMPKSPQGLSSGFTDSWRSDH 394

  Fly   634 ELHHSEMSNDPRXRSFGPSSSSQSSLGGLRKTSLKVPVYEIC 675
            ....:.|.|:   .|:....:|         .||||....||
Zfish   395 ASSSAVMLNE---NSYDEPDTS---------LSLKVHQVSIC 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	63/138 (46%)
Oamb	NP_001262774.1	7tm_1	37..>181	CDD:278431	64/143 (45%)
adra1ab	XP_021334987.1	7tm_GPCRs	48..349	CDD:333717	140/557 (25%)
		TM helix 2	72..94	CDD:320095	13/21 (62%)
		TM helix 3	110..132	CDD:320095	13/21 (62%)
		TM helix 4	155..171	CDD:320095	5/15 (33%)
		TM helix 5	192..215	CDD:320095	10/22 (45%)
		TM helix 6	280..305	CDD:320095	15/24 (63%)
		TM helix 7	317..342	CDD:320095	14/28 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1095345at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010