Protein Alignment Oamb and drd4-rs

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_001012638.3
• Gene: drd4-rs / 503566
• ZFINID: ZDB-GENE-051113-172
• Length: 418
• Species: Danio rerio
• Alignment Length: 568
• Identity: 147/568 - (25%)
• Similarity: 217/568 - (38%)
• Gaps: 193/568 - (33%)

  Fly    32 VLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKVWIFGDLW---- 92
            :::|.||.||..:|.....|::.||:|||:|||||||:.:.|||.....|     ..|.:|
Zfish    30 LIIILGNVLVCLSVLTERSLKTATNYFIVSLAVADLLLAILVLPLYVYSE-----FLGGIWTLSM 89

  Fly    93 --CRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFICFPP 155
              |...:.:||.:||||||||||||:|||:||..|:.|.....:.:..:||...||||..:..|.
Zfish    90 YICDALMTMDVMLCTASILNLCAISVDRYIAVVVPLKYNRNQFSVRQLALITATWVLSLGVASPV 154

  Fly   156 LVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNAYNPY 220
            :.|
Zfish   155 IFG-------------------------------------------------------------- 157

  Fly   221 DPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISGSCPW 285
                                                           ||..|...|..
Zfish   158 -----------------------------------------------LNQVPNRNPHV------- 168

  Fly   286 KCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGF--KTTKGSKGIGSRFEE 348
             |:| .|..:|:||::.||::|..||||.|:.::|...|.:...|:..  :..:|.:.:..|.
Zfish   169 -CKL-EDNQFVVYSSVCSFFVPCPVMLFLYYWMFRGLKRWSSGRNRSHLRRPPRGRRSLSLRL-- 229

  Fly   349 QRLTLRIHRGRGSNQQDSMHSNG-STQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPSSE 412
             ...|:..:||...:...:...| |..|.|.|..||                    ||.:.|.:.
Zfish   230 -GAALQKEKGRAREKVVYLMPAGLSPTSLTATPTTP--------------------ISSTSPVTL 273

  Fly   413 NISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKG-LPEL 476
            ...:||.....|.|.......:.:|. :..|...:||....|:.           .|||. .|..
Zfish   274 TTDDLAEGQMPGAESDPMTTQMDSVS-DAENPERATEDDSGREN-----------GVGKNHRPHT 326

  Fly   477 ARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYII 541
            .||           ||: :|:..||            |.||.|.|.::||:|:.||.|||.:::.
Zfish   327 GRR-----------HSK-SNRVSGR------------ERKAMKVLPVVVGVFLACWTPFFVVHVT 367

  Fly   542 RPFCQDC-VDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIIC 588
            :..|:.| :.|.|.||:.||||.||||||:||..|:.:||..|.:::|
Zfish   368 KALCESCDIGPTLISVVTWLGYVNSAVNPIIYTAFNVEFRNVFHKLLC 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	145/561 (26%)
		TM helix 1	22..48	CDD:320191	6/15 (40%)
		TM helix 2	55..81	CDD:320191	15/25 (60%)
		TM helix 3	93..123	CDD:320191	19/29 (66%)
		TM helix 4	135..158	CDD:320191	7/22 (32%)
		TM helix 5	292..321	CDD:320191	12/28 (43%)
		TM helix 6	512..542	CDD:320191	13/29 (45%)
		TM helix 7	551..576	CDD:320191	16/24 (67%)
drd4-rs	NP_001012638.3	7tmA_D4_dopamine_R	19..410	CDD:320434	145/561 (26%)
		TM helix 1	20..46	CDD:320434	6/15 (40%)
		TM helix 2	53..79	CDD:320434	15/25 (60%)
		TM helix 3	92..122	CDD:320434	19/29 (66%)
		TM helix 4	134..157	CDD:320434	7/22 (32%)
		TM helix 5	173..202	CDD:320434	12/28 (43%)
		TM helix 6	338..368	CDD:320434	15/41 (37%)
		TM helix 7	378..403	CDD:320434	16/24 (67%)