Protein Alignment Oamb and 5-HT1A

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Alignment Length: 756
• Identity: 165/756 - (21%)
• Similarity: 262/756 - (34%)
• Gaps: 299/756 - (39%)

  Fly     7 EDLIKSVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGL 71
            :|..:.::....:.|:.|.:|     :.|.||..||||:.....|::|.|:.:.:||||||.|..
  Fly   218 DDFTQLLRMAVTSVLLGLMIL-----VTIIGNVFVIAAIILERNLQNVANYLVASLAVADLFVAC 277

  Fly    72 AVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKK 136
            .|:|..|.:|:.:.||.|...|.||.:.||..||||||:|.||::|||.|||. :.|....::.:
  Fly   278 LVMPLGAVYEISQGWILGPELCDIWTSCDVLCCTASILHLVAIAVDRYWAVTN-IDYIHSRTSNR 341

  Fly   137 AKSLIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGE 201
            ...:|..:|..:..:...|..||||      |.|                      |..|:.|
  Fly   342 VFMMIFCVWTAAVIVSLAPQFGWKD------PDY----------------------LQRIEQQ-- 376

  Fly   202 ASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLD 266
                                                                             
  Fly   377 ----------------------------------------------------------------- 376

  Fly   267 LLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAA-----VRTT 326
                               ||.::.|..|.:::...:||:|:.|:|..||:||:.|     .|..
  Fly   377 -------------------KCMVSQDVSYQVFATCCTFYVPLLVILALYWKIYQTARKRIHRRRP 422

  Fly   327 RAINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHS-----------------NGSTQ 374
            |.::......:...|..:..:..||.||:  ||.|..:....|                 :|::.
  Fly   423 RPVDAAVNNNQPDGGAATDTKLHRLRLRL--GRFSTAKSKTGSAVGVSGPASGGRALGLVDGNST 485

  Fly   375 STTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPSSENISELAGHGDVGH-------ERRQSGN 432
            :|..|:..      :::::..:  ..|.:..|..||:.. :::|   .|.|       :.:.:..
  Fly   486 NTVNTVED------TEFSSSNV--DSKSRAGVEAPSTSG-NQIA---TVSHLVALAKQQGKSTAK 538

  Fly   433 ALFAVHYNGTNGRESTESQ------------LYRQQQQHG----VASSCYLQVG----------- 470
            :..||:....:||:..:.|            |..|.:|.|    .|:|.....|
  Fly   539 SSAAVNGMAPSGRQEDDGQRPEHGEQEDREELEDQDEQVGPQPTTATSAMTAAGTNESEDQCKAN 603

  Fly   471 -----------KGLPELARRQSNTSEAGGSG---------------------------------- 490
                       :.|.::.:.|.:....||.|
  Fly   604 GVEVLEDPQLQQQLEQVQQLQKSVKSGGGGGASTSNATTITSISALSPQTPTSQGVGIAAAAAGP 668

  Fly   491 ------------HSRP-------------------------------------------AN--KK 498
                        .|.|                                           ||  :|
  Fly   669 MTAKTSTLTSCNQSHPLCGTANESPSTPEPRSRQPTTPQQQPHQQAHQQQQQQQQLSSIANPMQK 733

  Fly   499 MGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQDC-VDPLLFSVLFWLGY 562
            :.:|....:.||   |.|||||||||.|.|:.||.|||.|.:..|.|..| :...:.|:..||||
  Fly   734 VNKRKETLEAKR---ERKAAKTLAIITGAFVVCWLPFFVMALTMPLCAACQISDSVASLFLWLGY 795

  Fly   563 CNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSVSLKSSR 603
            .||.:||:||.:||.:||.|||||:   |...:.|..:|.:
  Fly   796 FNSTLNPVIYTIFSPEFRQAFKRIL---FGGHRPVHYRSGK 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	156/720 (22%)
		TM helix 1	22..48	CDD:320191	9/25 (36%)
		TM helix 2	55..81	CDD:320191	11/25 (44%)
		TM helix 3	93..123	CDD:320191	18/29 (62%)
		TM helix 4	135..158	CDD:320191	3/22 (14%)
		TM helix 5	292..321	CDD:320191	11/28 (39%)
		TM helix 6	512..542	CDD:320191	18/29 (62%)
		TM helix 7	551..576	CDD:320191	11/24 (46%)
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	73/305 (24%)
		TM helix 1	228..254	CDD:320454	10/30 (33%)
		TM helix 2	261..287	CDD:320454	11/25 (44%)
		TM helix 3	299..329	CDD:320454	18/29 (62%)
		TM helix 4	340..362	CDD:320454	3/21 (14%)
		TM helix 5	383..412	CDD:320454	11/28 (39%)
		7tm_GPCRs	<743..816	CDD:475119	38/75 (51%)
		TM helix 6	750..772	CDD:410628	15/21 (71%)
		TM helix 7	784..809	CDD:410628	11/24 (46%)