Protein Alignment Oamb and HTR5A

DIOPT Version :9

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_076917.1
• Gene: HTR5A / 3361
• HGNCID: 5300
• Length: 357
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 128/598 - (21%)
• Similarity: 196/598 - (32%)
• Gaps: 277/598 - (46%)

  Fly     7 EDLIKSVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGL 71
            :||..|........::.|.:|.|:.......|.||:|.:........|.:..:.::||:|:||..
Human    27 DDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAA 91

  Fly    72 AVLPFSATWEVF-KVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTK 135
            .|:|.|...|:. :.|..|...|::|:|.||..|||||.|:.||:||||.::||.:.|  .:.|:
Human    92 LVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEY--TLRTR 154

  Fly   136 KAKS--LIAGIWVLSFFICFPPLV-GWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIK 197
            |..|  :||..|.||..|...||: ||
Human   155 KCVSNVMIALTWALSAVISLAPLLFGW-------------------------------------- 181

  Fly   198 DQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETE 262
                            |..|:         :||.|
Human   182 ----------------GETYS---------EGSEE------------------------------ 191

  Fly   263 MDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTR 327
                                    |:::.:..|.::|.:|:||:|:.|:||.||:||:||
Human   192 ------------------------CQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAA----- 227

  Fly   328 AINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYA 392
                .|:       :|||                          .|.|.     :|..|.:
Human   228 ----KFR-------VGSR--------------------------KTNSV-----SPISEAV---- 246

  Fly   393 TRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGREST-----ESQL 452
                    ::|.|...|                      ..:|.|       |.:|     |...
Human   247 --------EVKDSAKQP----------------------QMVFTV-------RHATVTFQPEGDT 274

  Fly   453 YRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKA 517
            :|:|:                                                        |.:|
Human   275 WREQK--------------------------------------------------------EQRA 283

  Fly   518 AKTLAIIVGMFIFCWCPFFTMYIIRPFCQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFA 582
            |..:.|::|:|:.||.|||...:|.|.|...:..:..|:..||||.||..||:||..|:|::..|
Human   284 ALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSA 348

  Fly   583 FKRIICRCFCSRQ 595
            ||.     |.|||
Human   349 FKN-----FFSRQ 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	46/127 (36%)
		7tm_1	37..>181	CDD:278431	49/147 (33%)
HTR5A	NP_076917.1	7tmA_5-HT5	41..349	CDD:320451	118/570 (21%)
		TM helix 1	42..68	CDD:320451	7/25 (28%)
		TM helix 2	75..101	CDD:320451	8/25 (32%)
		TM helix 3	114..144	CDD:320451	17/29 (59%)
		TM helix 4	156..177	CDD:320451	7/20 (35%)
		TM helix 5	197..226	CDD:320451	13/28 (46%)
		TM helix 6	278..308	CDD:320451	12/85 (14%)
		TM helix 7	317..342	CDD:320451	11/24 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910