Protein Alignment Oamb and HTR2C

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_000859.2
• Gene: HTR2C / 3358
• HGNCID: 5295
• Length: 458
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 139/642 - (21%)
• Similarity: 217/642 - (33%)
• Gaps: 265/642 - (41%)

  Fly    20 NLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFK 84
            |..:|::: .|.::.||||.|||.||....||.:.||:|:::||:||:||||.|:|.|....::.
Human    54 NWPALSIV-IIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYD 117

  Fly    85 -VWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLS 148
             ||......|.:|:::||...||||::|||||||||||:..|:.:....|..||...||.:|.:|
Human   118 YVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAIS 182

  Fly   149 FFICFP-PLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIG 212
            ..:..| |::|.:|::.|.
Human   183 IGVSVPIPVIGLRDEEKVF---------------------------------------------- 201

  Fly   213 NGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQ 277
                                     :::|:
Human   202 -------------------------VNNTT----------------------------------- 206

  Fly   278 TISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGI 342
                     |.| ||..:||..:..:|:||:.:|:..|.
Human   207 ---------CVL-NDPNFVLIGSFVAFFIPLTIMVITYC-------------------------- 235

  Fly   343 GSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVS 407
                    ||:.:                                |.:.|...||
Human   236 --------LTIYV--------------------------------LRRQALMLLH---------- 250

  Fly   408 YPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKG 472
                            ||.....|.:|..:.....|..|...|....|.|.
Human   251 ----------------GHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQN-------------- 285

  Fly   473 LPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFT 537
                |||:                ||..||. :..::....|.||:|.|.|:..:|:..|||||.
Human   286 ----ARRR----------------KKKERRP-RGTMQAINNERKASKVLGIVFFVFLIMWCPFFI 329

  Fly   538 MYIIRPFCQ-DCVDPL---LFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSVS 598
            ..|:...|: .|...|   |.:|..|:||..|.:||::|.||:|.:|.||...: ||   ...|.
Human   330 TNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYL-RC---NYKVE 390

  Fly   599 LKSSRR-----------GSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMSNDP 644
            .|...|           |.:::....|.....:...|:.:..|.|.::.:.|:..:|
Human   391 KKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNP 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	124/567 (22%)
		TM helix 1	22..48	CDD:320191	11/25 (44%)
		TM helix 2	55..81	CDD:320191	14/25 (56%)
		TM helix 3	93..123	CDD:320191	19/29 (66%)
		TM helix 4	135..158	CDD:320191	8/23 (35%)
		TM helix 5	292..321	CDD:320191	8/28 (29%)
		TM helix 6	512..542	CDD:320191	13/29 (45%)
		TM helix 7	551..576	CDD:320191	11/27 (41%)
HTR2C	NP_000859.2	7tmA_5-HT2C	54..385	CDD:341346	127/575 (22%)
		TM helix 1	55..81	CDD:341346	11/26 (42%)
		TM helix 2	88..114	CDD:341346	14/25 (56%)
		TM helix 3	127..157	CDD:341346	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	151..153		1/1 (100%)
		TM helix 4	169..192	CDD:341346	8/22 (36%)
		TM helix 5	211..240	CDD:341346	10/62 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	274..301		10/61 (16%)
		TM helix 6	304..334	CDD:341346	13/29 (45%)
		TM helix 7	347..372	CDD:341346	10/24 (42%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	364..368		2/3 (67%)
		PDZ-binding	456..458