Protein Alignment Oamb and HTR2A

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_000612.1
• Gene: HTR2A / 3356
• HGNCID: 5293
• Length: 471
• Species: Homo sapiens
• Alignment Length: 663
• Identity: 142/663 - (21%)
• Similarity: 222/663 - (33%)
• Gaps: 296/663 - (44%)

  Fly    10 IKSVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVL 74
            ::...|:.   |::..|:    :|.|.||.|||.||....||::.||:|:::||:||:|:|..|:
Human    71 LQEKNWSA---LLTAVVI----ILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVM 128

  Fly    75 PFSATWEVFKVWIFGDLW------CRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMS 133
            |.|     ....::|..|      |.:|:.:||...||||::|||||||||||:..|:.:....|
Human   129 PVS-----MLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNS 188

  Fly   134 TKKAKSLIAGIWVLSFFICFP-PLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIK 197
            ..||...|..:|.:|..|..| |:.|.:|...|.:
Human   189 RTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFK------------------------------ 223

  Fly   198 DQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETE 262
                                                                             
Human   224 ----------------------------------------------------------------- 223

  Fly   263 MDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTR 327
                             .|||     |..|..:||..:..||:||:.:|:..|:
Human   224 -----------------EGSC-----LLADDNFVLIGSFVSFFIPLTIMVITYF----------- 255

  Fly   328 AINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYA 392
                                   ||::                                .|.|.|
Human   256 -----------------------LTIK--------------------------------SLQKEA 265

  Fly   393 TRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQ 457
            |          :.||              |:|                       |.::|
Human   266 T----------LCVS--------------DLG-----------------------TRAKL----- 278

  Fly   458 QHGVASSCYL-QVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTL 521
                ||..:| |......:|.:|         |.|..|.: ..|||.:::    ...|.||.|.|
Human   279 ----ASFSFLPQSSLSSEKLFQR---------SIHREPGS-YTGRRTMQS----ISNEQKACKVL 325

  Fly   522 AIIVGMFIFCWCPFFTMYIIRPFCQD-CVDPL---LFSVLFWLGYCNSAVNPMIYALFSKDFRFA 582
            .|:..:|:..|||||...|:...|:: |.:.:   |.:|..|:||.:|||||::|.||:|.:|.|
Human   326 GIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSA 390

  Fly   583 FKRIICRCFCSRQSVSLKSSRRGSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMSNDPRXR 647
            |.|.| :|       ..|.:::...:..:       :..|:.|..|    |:|...:..|..:..
Human   391 FSRYI-QC-------QYKENKKPLQLILV-------NTIPALAYKS----SQLQMGQKKNSKQDA 436

  Fly   648 SFGPSSSSQSSLG 660
            ....:..|..:||
Human   437 KTTDNDCSMVALG 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	126/573 (22%)
		TM helix 1	22..48	CDD:320191	10/25 (40%)
		TM helix 2	55..81	CDD:320191	12/25 (48%)
		TM helix 3	93..123	CDD:320191	19/29 (66%)
		TM helix 4	135..158	CDD:320191	8/23 (35%)
		TM helix 5	292..321	CDD:320191	9/28 (32%)
		TM helix 6	512..542	CDD:320191	13/29 (45%)
		TM helix 7	551..576	CDD:320191	12/27 (44%)
HTR2A	NP_000612.1	7tmA_5-HT2A	75..391	CDD:341345	127/580 (22%)
		TM helix 1	76..102	CDD:341345	12/32 (38%)
		TM helix 2	109..135	CDD:341345	12/30 (40%)
		TM helix 3	148..178	CDD:341345	19/29 (66%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	172..174		1/1 (100%)
		TM helix 4	190..213	CDD:341345	8/22 (36%)
		TM helix 5	231..260	CDD:341345	11/94 (12%)
		TM helix 6	316..346	CDD:341345	13/29 (45%)
		TM helix 7	359..384	CDD:341345	12/24 (50%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	376..380		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..471
		PDZ-binding. /evidence=ECO:0000269|PubMed:11150294, ECO:0000269|PubMed:14988405	469..471