Protein Alignment Oamb and HTR1E

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_000856.1
• Gene: HTR1E / 3354
• HGNCID: 5291
• Length: 365
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 143/604 - (23%)
• Similarity: 210/604 - (34%)
• Gaps: 257/604 - (42%)

  Fly     1 MNETECED----LIKSVKWTEPANL-ISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIV 60
            ||.|.|..    .|:....||...: ::|.|:..:..|:   |..||.|:..:.||....|:.|.
Human     1 MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLL---NLAVIMAIGTTKKLHQPANYLIC 62

  Fly    61 NLAVADLLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRP 125
            :|||.||||.:.|:|.|..:.|...|..|...|.:||:||:..||.|||:||.|:||||.|:|..
Human    63 SLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNA 127

  Fly   126 VTYPSIMSTKKAKSLIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQ 190
            :.|....:.|:|..:|..:|.:|.||..|||. |:..:.:
Human   128 IEYARKRTAKRAALMILTVWTISIFISMPPLF-WRSHRRL------------------------- 166

  Fly   191 LGLDSIKDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASS 255
                            |||
Human   167 ----------------SPP---------------------------------------------- 169

  Fly   256 SSTTETEMDLDLLNAPPQNRPQTISGSCPWKCELTNDRG-YVLYSALGSFYIPMFVMLFFYWRIY 319
                                        |.:|.:.:|.. |.:||.||:||||:.::|..|:|||
Human   170 ----------------------------PSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIY 206

  Fly   320 RAAVRTTRAINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTT------ 378
            .||    :::.|    .:||    ||....|.|            ||.:|..|.:.|.|
Human   207 HAA----KSLYQ----KRGS----SRHLSNRST------------DSQNSFASCKLTQTFCVSDF 247

  Fly   379 TLGTPSPERLSKYATRRLHHHDKIKISVSYPSSENISELAGHGDVGH--ERRQSGNALFAVHYNG 441
            :...|:.|            .:|...|:..|..:|        |:.|  ||:|
Human   248 STSDPTTE------------FEKFHASIRIPPFDN--------DLDHPGERQQ------------ 280

  Fly   442 TNGRESTESQLYRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKA 506
                               ::|:
Human   281 -------------------ISST------------------------------------------ 284

  Fly   507 QVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQDCVDPLLFSVLFWLGYCNSAVNPMI 571
                  .|.|||:.|.:|:|.||..|.|||...:|.......|...:...|.||||.||.:||::
Human   285 ------RERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLL 343

  Fly   572 YALFSKDFRFAFKRII-CR 589
            |..|::||:.|||::| ||
Human   344 YTSFNEDFKLAFKKLIRCR 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	130/571 (23%)
		TM helix 1	22..48	CDD:320191	7/25 (28%)
		TM helix 2	55..81	CDD:320191	12/25 (48%)
		TM helix 3	93..123	CDD:320191	18/29 (62%)
		TM helix 4	135..158	CDD:320191	10/22 (45%)
		TM helix 5	292..321	CDD:320191	15/29 (52%)
		TM helix 6	512..542	CDD:320191	13/29 (45%)
		TM helix 7	551..576	CDD:320191	10/24 (42%)
HTR1E	NP_000856.1	7tmA_5-HT1E	23..355	CDD:320457	130/573 (23%)
		TM helix 1	24..50	CDD:320457	7/28 (25%)
		TM helix 2	57..83	CDD:320457	12/25 (48%)
		TM helix 3	95..125	CDD:320457	18/29 (62%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	119..121		1/1 (100%)
		TM helix 4	137..159	CDD:320457	9/21 (43%)
		TM helix 5	179..208	CDD:320457	14/28 (50%)
		TM helix 6	284..314	CDD:320457	13/77 (17%)
		TM helix 7	323..348	CDD:320457	10/24 (42%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	340..344		2/3 (67%)