Protein Alignment Oamb and Octalpha2R

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: XP_061501849.1
• Gene: Octalpha2R / 3289716
• VectorBaseID: AGAMI1_006243
• Length: 636
• Species: Anopheles gambiae
• Alignment Length: 671
• Identity: 177/671 - (26%)
• Similarity: 259/671 - (38%)
• Gaps: 215/671 - (32%)

  Fly    15 WTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSAT 79
            :|.|..:|:..::..:.::::.||.|||.|:.....|:::.|:||.:|||||..:||.::|||..
Mosquito    81 YTLPHIIIASIIVTILMIVIVVGNMLVIIAIATEKTLKNIQNWFIASLAVADFFLGLVIMPFSLA 145

  Fly    80 WEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGI 144
            .|:...||||:.||.:..|:||.:||:||:|||.||||||.::|:.:.|....:..:|..:||.:
Mosquito   146 NELMGYWIFGNWWCDVHSAMDVLLCTSSIMNLCLISLDRYWSITKAIEYLKSRTPARAAFMIAAV 210

  Fly   145 WVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPP 209
            |::|..:|.|||:|||.|                                  :.:|...||
Mosquito   211 WIMSALVCIPPLLGWKAQ----------------------------------RPEGHVELP---- 237

  Fly   210 HIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQN 274
                                                                             
Mosquito   238 ----------------------------------------------------------------- 237

  Fly   275 RPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAA-VRTTRAI--------- 329
                       :|:|:.|.||||||||||||||..:|:|.|.|||.|| .|..|.|
Mosquito   238 -----------QCQLSQDIGYVLYSALGSFYIPSCIMVFVYIRIYFAAKARARRGIRKKPLKPPS 291

  Fly   330 --------NQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTT---TTLGTP 383
                    |.|...........|...:.......|:.............||||..|   ...|||
Mosquito   292 EQDTSFTRNAGTVPMPSLPSASSNNNQSAAAAAHHQQHPVQLSSGAQGGGSTQIATIEPPPRGTP 356

  Fly   384 SP-----------ERLSKYATRRLHHHDKIK-ISVSYPSSENISELAGHGDVGHERRQSGNALFA 436
            .|           ...|:.||.....|..|. :::....:..:::.|..|...:....:|.|...
Mosquito   357 MPIPVVTCDFASDMSTSEAATAEQDQHGPISPVALEPKDTLKVTQPAQQGRSTNGITAAGAATEP 421

  Fly   437 VHYNGTNGRESTE----------SQLYRQQQQHGVASSCYLQ-----------VGKGLPELARRQ 480
            |....:....|..          |:........||.|.|.:.           .|||  :...||
Mosquito   422 VASPSSAAARSRALSVGIDTDMVSEFDPSSSDSGVISRCAVVKPLKFRLCQPIFGKG--KAKARQ 484

  Fly   481 SNTSEAG------GSGHSRPANKKM-----GRRNI------------------------------ 504
            :|...||      |.|::....:.|     |::.|
Mosquito   485 ANAKAAGHGGAHAGRGNAPNCTQPMLAAPGGQQAISQLIAAKQTDSACSELEPALPPKPKPRDPE 549

  Fly   505 --KAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQDC-VDPLLFSVLFWLGYCNSA 566
              |.::.| :.|.:|...|.:|:|.||.||.|||.:||:.|.|.|| :....||:.|||||.|||
Mosquito   550 KEKRRIAR-KKEKRATLILGLIMGSFIACWLPFFFLYILVPVCPDCHIPDSAFSLAFWLGYMNSA 613

  Fly   567 VNPMIYALFSKDFRFAFKRII 587
            :||.||.:|:||||.||:||:
Mosquito   614 LNPAIYTIFNKDFRRAFRRIL 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	171/659 (26%)
		TM helix 1	22..48	CDD:320191	7/25 (28%)
		TM helix 2	55..81	CDD:320191	13/25 (52%)
		TM helix 3	93..123	CDD:320191	17/29 (59%)
		TM helix 4	135..158	CDD:320191	9/22 (41%)
		TM helix 5	292..321	CDD:320191	21/28 (75%)
		TM helix 6	512..542	CDD:320191	14/29 (48%)
		TM helix 7	551..576	CDD:320191	14/24 (58%)
Octalpha2R	XP_061501849.1	None