Protein Alignment Oamb and HRH2

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_001354640.1
• Gene: HRH2 / 3274
• HGNCID: 5183
• Length: 422
• Species: Homo sapiens
• Alignment Length: 696
• Identity: 141/696 - (20%)
• Similarity: 215/696 - (30%)
• Gaps: 348/696 - (50%)

  Fly     1 MNETECEDLIKSVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVA 65
            ::.|.|:..|..|          ||||..|.|   .||.:|..||..:.:||::||.|||:||:.
Human    12 LDSTACKITITVV----------LAVLILITV---AGNVVVCLAVGLNRRLRNLTNCFIVSLAIT 63

  Fly    66 DLLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPS 130
            |||:||.||||||.:::...|.||.::|.|:.::||.:||||||||..||||||.||..|:.||.
Human    64 DLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPV 128

  Fly   131 IMSTKKAKSLIAGIWVLSFFICFPPL-VGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLD 194
            :::..:....:..|||:|..:.|..: :||..:...     .|||||
Human   129 LVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNET-----SKGNHT------------------ 170

  Fly   195 SIKDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTT 259
                                                            ||
Human   171 ------------------------------------------------TS--------------- 172

  Fly   260 ETEMDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVR 324
                                      ||::..:..|.|...|.:||:|:.:|...|:||::.|..
Human   173 --------------------------KCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARD 211

  Fly   325 TTRAINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLS 389
            ..:.||                                                        .:|
Human   212 QAKRIN--------------------------------------------------------HIS 220

  Fly   390 KYATRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYR 454
            .:....:..|
Human   221 SWKAATIREH------------------------------------------------------- 230

  Fly   455 QQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAK 519
                                                                         ||..
Human   231 -------------------------------------------------------------KATV 234

  Fly   520 TLAIIVGMFIFCWCPFFTMYIIRPF-CQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAF 583
            |||.::|.||.||.|:||.::.|.. ..|.::.:|.:::.||||.|||:||::||..::|||..:
Human   235 TLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGY 299

  Fly   584 KRIICRCFCSRQSVSLKSSRRGSDMSAIRIRARTP----------------SIT-PSAAA----- 626
            :::.|....:|.  |.|:|.|.:.....|.::|.|                .:| |..|.
Human   300 QQLFCCRLANRN--SHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRKPA 362

  Fly   627 -------------------------HSFGDESELHHSEMSNDPRXR 647
                                     |..|...||....:|.:|:.|
Human   363 LSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKR 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	118/563 (21%)
		TM helix 1	22..48	CDD:320191	11/25 (44%)
		TM helix 2	55..81	CDD:320191	18/25 (72%)
		TM helix 3	93..123	CDD:320191	19/29 (66%)
		TM helix 4	135..158	CDD:320191	5/23 (22%)
		TM helix 5	292..321	CDD:320191	10/28 (36%)
		TM helix 6	512..542	CDD:320191	13/29 (45%)
		TM helix 7	551..576	CDD:320191	12/24 (50%)
HRH2	NP_001354640.1	7tmA_Histamine_H2R	19..299	CDD:320179	120/576 (21%)
		TM helix 1	20..46	CDD:320179	13/38 (34%)
		TM helix 2	53..80	CDD:320179	18/26 (69%)
		TM helix 3	91..121	CDD:320179	19/29 (66%)
		TM helix 4	133..153	CDD:320179	5/19 (26%)
		TM helix 5	179..209	CDD:320179	10/29 (34%)
		TM helix 6	227..257	CDD:320179	14/145 (10%)
		TM helix 7	267..292	CDD:320179	12/24 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..340		5/23 (22%)