Protein Alignment Oamb and mAChR-C

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_572358.1
• Gene: mAChR-C / 31626
• FlyBaseID: FBgn0029909
• Length: 371
• Species: Drosophila melanogaster
• Alignment Length: 608
• Identity: 116/608 - (19%)
• Similarity: 172/608 - (28%)
• Gaps: 313/608 - (51%)

  Fly     3 ETECEDLIKSVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSV-TNFFIVNLAVAD 66
            ||..|..:::..: ...:|:.||:..|:.||::|||.|.|.||.....|||| :|.||::|||:|
  Fly    34 ETPTEITLQATSF-GAGHLLWLAINAFLFVLILGGNILTIVAVRTCRHLRSVISNLFILSLAVSD 97

  Fly    67 LLVGLAVLPFSATWEVFKVWIFGDLW-----CRIWLAVDVWMCTASILNLCAISLDRYVAVTRPV 126
            ..|||| ||:...:     ::..|:.     |.:...:.:..|..|:|.|.:|::|||:||...:
  Fly    98 FCVGLA-LPYHLVF-----YMGSDIGAMRGPCLLRFFLLICACCVSMLTLISIAVDRYIAVVYAL 156

  Fly   127 TYPSIMSTKKAKSLIAGIWVLSFFICFPPLV--GWKDQKA-----VIQPTYPKGNHTLYYTTTMS 184
            .|...|:.:.|.|:|...|.|...:...|:.  .|.|.:|     |:.|.|..|..|
  Fly   157 HYRRYMTRRVAYSIIIFNWCLGALVALLPVFWNRWPDAQACEFDEVLAPGYIAGVIT-------- 213

  Fly   185 SSEDGQLGLDSIKDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATT 249
                                                 |||..|
  Fly   214 -------------------------------------PGFVII---------------------- 219

  Fly   250 TTTASSSSTTETEMDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFF 314
                                               |.|                       |...
  Fly   220 -----------------------------------WIC-----------------------MFLV 226

  Fly   315 YWRIYRAAVRTTRAINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTT 379
            ||||.|.|
  Fly   227 YWRIMREA--------------------------------------------------------- 234

  Fly   380 LGTPSPERLSKYATRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNG 444
                     ||.|.|       ::.||.|
  Fly   235 ---------SKQALR-------LRQSVVY------------------------------------ 247

  Fly   445 RESTESQLYRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVK 509
                                                 ||.||            ...||:
  Fly   248 -------------------------------------NTDEA------------TTMRNL----- 258

  Fly   510 RFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIRPF--CQDCVDPLLFSVLFWLGYCNSAVNPMIY 572
            ....:.|:.:.:..|:|.|..||.|:|.:.|.:.|  ||.  ..:::...|.|...|||:||:||
  Fly   259 LLHPDWKSVQIVVFIMGCFTLCWLPYFCVAIAQLFSICQS--SSMIYKTTFSLAIANSALNPIIY 321

  Fly   573 ALFSKDFRFAFKRIICRCFCSRQ 595
            :..:..||.||.:.:| |..:||
  Fly   322 SWKNSGFRRAFVQTLC-CRTARQ 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	107/576 (19%)
		TM helix 1	22..48	CDD:320191	12/25 (48%)
		TM helix 2	55..81	CDD:320191	13/25 (52%)
		TM helix 3	93..123	CDD:320191	10/29 (34%)
		TM helix 4	135..158	CDD:320191	6/24 (25%)
		TM helix 5	292..321	CDD:320191	5/28 (18%)
		TM helix 6	512..542	CDD:320191	9/29 (31%)
		TM helix 7	551..576	CDD:320191	9/24 (38%)
mAChR-C	NP_572358.1	7tm_classA_rhodopsin-like	53..325	CDD:410626	104/567 (18%)
		TM helix 1	53..78	CDD:410626	12/24 (50%)
		TM helix 2	86..111	CDD:410626	13/30 (43%)
		TM helix 3	123..153	CDD:410626	10/29 (34%)
		TM helix 4	166..185	CDD:410626	5/18 (28%)
		TM helix 5	204..229	CDD:410626	12/149 (8%)
		TM helix 6	261..291	CDD:410626	9/29 (31%)
		TM helix 7	300..325	CDD:410626	9/24 (38%)