DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oamb and Adra1d

DIOPT Version :9

Sequence 1:	NP_001262774.1	Gene:	Oamb / 43982	FlyBaseID:	FBgn0024944	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_077809.2	Gene:	Adra1d / 29413	RGDID:	62064	Length:	562	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	187/705 - (26%)
Similarity:	267/705 - (37%)	Gaps:	287/705 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKVW 86
            :.:.:..|| :..:.||.|||.:|.|:..|::|||:|||||||||||:..||||||||.||...|
  Rat    93 VGVFLAAFI-LTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFW 156

  Fly    87 IFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFI 151
            .||..:|.:|.||||..||||||:||.||:||||.|...:.||:||:.:||.:::|.:|.::..:
  Rat   157 AFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVV 221

  Fly   152 CFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNA 216
            ...||:|||:                                            |.||
  Rat   222 SVGPLLGWKE--------------------------------------------PVPP------- 235

  Fly   217 YNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISG 281
                |..|
  Rat   236 ----DERF--------------------------------------------------------- 239

  Fly   282 SCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSRF 346
                 |.:|.:.||.::|::.|||:||.|::..|.|:|..|..|||::..|.|...|
  Rat   240 -----CGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPG-------- 291

  Fly   347 EEQRLTLRIH-RGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPS 410
            :...:.|||| ||                :.|:..|                          ||.
  Rat   292 KASEVVLRIHCRG----------------AATSAKG--------------------------YPG 314

  Fly   411 SENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGLPE 475
            :::
  Rat   315 TQS-------------------------------------------------------------- 317

  Fly   476 LARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYI 540
                        ..||:.       |.::..::.:|..|.||||||||:||:|:.||.|||   .
  Rat   318 ------------SKGHTL-------RSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFF---F 360

  Fly   541 IRP----FCQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSVSL-- 599
            :.|    |.|......:|.|:|||||.||.|||:||...|::|:.||.|:: ||.|.|:...|
  Rat   361 VLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLL-RCQCRRRRRRLWR 424

  Fly   600 --KSSRRGSDMSAIRIRARTPSITPSAA-----AHSFGDESELHHSEMSNDPRXRSFGPSSSSQS 657
              ....|.|...|....|.:|.|.|..|     ||.....::...::   |.. .|..|:|:.:.
  Rat   425 VYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQ---DSVSSSRKPASALRE 486

  Fly   658 --SLGGLRK--TSLKVPVYEICHPL------VMETAC--YSYVEATS-----DGS 695
              .||.|::  |.|:..|..:.|.:      ..||||  .|.|||.|     ||:
  Rat   487 WRLLGPLQRPTTQLRAKVSSLSHKIRSGGARRAETACALRSEVEAVSLNVPQDGA 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	66/124 (53%)
Oamb	NP_001262774.1	7tm_1	37..>181	CDD:278431	69/143 (48%)
Adra1d	NP_077809.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	10..71
		7tm_GPCRs	91..407	CDD:421689	147/565 (26%)
		TM helix 1	92..118	CDD:410628	8/25 (32%)
		TM helix 2	125..151	CDD:410628	21/25 (84%)
		TM helix 3	163..193	CDD:410628	20/29 (69%)
		TM helix 4	205..228	CDD:410628	6/22 (27%)
		TM helix 5	245..274	CDD:410628	12/28 (43%)
		TM helix 6	335..365	CDD:410628	18/32 (56%)
		TM helix 7	375..400	CDD:410628	14/24 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..481		5/31 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1095345at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010