Protein Alignment Oamb and Adra1a

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_058887.2
• Gene: Adra1a / 29412
• RGDID: 2055
• Length: 466
• Species: Rattus norvegicus
• Alignment Length: 695
• Identity: 170/695 - (24%)
• Similarity: 244/695 - (35%)
• Gaps: 314/695 - (45%)

  Fly    18 PANLISLAVLEFI--NVLVIG--GNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSA 78
            |.|:....:|..|  .:::.|  ||.|||.:|.|...|.|||:::||||||||||:...||||||
  Rat    20 PVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSA 84

  Fly    79 TWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAG 143
            .:|:...|.||.::|.||.||||..|||||:.||.||:|||:.|:.|:.||:|::.::....:..
  Rat    85 IFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLC 149

  Fly   144 IWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSP 208
            :||||..|...||.||:      ||
  Rat   150 VWVLSLVISIGPLFGWR------QP---------------------------------------- 168

  Fly   209 PHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQ 273
                            ||.|
  Rat   169 ----------------APED--------------------------------------------- 172

  Fly   274 NRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKG 338
               :||       |::..:.||||:|||||||:|:.::|..|.|:|..|.|.:|.:..|.||.|.
  Rat   173 ---ETI-------CQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKS 227

  Fly   339 SKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIK 403
                    :.:::||||||
  Rat   228 --------DSEQVTLRIHR---------------------------------------------- 238

  Fly   404 ISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQ 468
                                                                             
  Rat   239 ----------------------------------------------------------------- 238

  Fly   469 VGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWC 533
              |.:|           |.|.|.|...||    .:...::.:|..|.||||||.|:||.|:.||.
  Rat   239 --KNVP-----------AEGGGVSSAKNK----THFSVRLLKFSREKKAAKTLGIVVGCFVLCWL 286

  Fly   534 PFFTMYIIRPFCQDC-VDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSV 597
            |||.:..|..|..|. ....:|.::|||||.||.:||:||...|::|:.||:.:: |..|.|
  Rat   287 PFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL-RIQCLR--- 347

  Fly   598 SLKSSRRGSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMSNDPRXRSFGPSSSSQSSLGGL 662
                 ||.|...|:......||                                     .:|.|.
  Rat   348 -----RRQSSKHALGYTLHPPS-------------------------------------QALEGQ 370

  Fly   663 RKTSLKVPV------YEICHPLVMETAC-YSYVEATSDGSASCSV 700
            .:..:::||      |:|..   .:..| :.:..:...|||..:|
  Rat   371 HRDMVRIPVGSGETFYKISK---TDGVCEWKFFSSMPQGSARITV 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	146/566 (26%)
		TM helix 1	22..48	CDD:320191	9/29 (31%)
		TM helix 2	55..81	CDD:320191	17/25 (68%)
		TM helix 3	93..123	CDD:320191	19/29 (66%)
		TM helix 4	135..158	CDD:320191	7/22 (32%)
		TM helix 5	292..321	CDD:320191	16/28 (57%)
		TM helix 6	512..542	CDD:320191	16/29 (55%)
		TM helix 7	551..576	CDD:320191	12/24 (50%)
Adra1a	NP_058887.2	7tmA_alpha1A_AR	27..337	CDD:320448	146/562 (26%)
		TM helix 1	28..54	CDD:320448	9/25 (36%)
		TM helix 2	61..87	CDD:320448	17/25 (68%)
		TM helix 3	99..129	CDD:320448	19/29 (66%)
		TM helix 4	141..164	CDD:320448	7/22 (32%)
		TM helix 5	181..210	CDD:320448	16/28 (57%)
		TM helix 6	265..295	CDD:320448	16/29 (55%)
		TM helix 7	305..330	CDD:320448	12/24 (50%)
		Nuclear localization signal. /evidence=ECO:0000250	334..349		5/23 (22%)