Protein Alignment Oamb and Drd3

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_058836.1
• Gene: Drd3 / 29238
• RGDID: 2521
• Length: 446
• Species: Rattus norvegicus
• Alignment Length: 594
• Identity: 150/594 - (25%)
• Similarity: 217/594 - (36%)
• Gaps: 232/594 - (39%)

  Fly    34 VIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVF-----KVWIFGDLWC 93
            :|.||.||.|||.....|::.||:.:|:||||||||...|:|    |.|:     .||.|..:.|
  Rat    43 IIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMP----WVVYLEVTGGVWNFSRICC 103

  Fly    94 RIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTY---PSIMSTKKAKSLIAGIWVLSFFICFPP 155
            .:::.:||.|||||||||||||:|||.||..||.|   ....|.::...:|..:|||:|.:..|.
  Rat   104 DVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPL 168

  Fly   156 LVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNAYNPY 220
            |.|                    :.||                 |:.|:
  Rat   169 LFG--------------------FNTT-----------------GDPSI---------------- 180

  Fly   221 DPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISGSCPW 285
                                                                             
  Rat   181 ----------------------------------------------------------------- 180

  Fly   286 KCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSR--FEE 348
             |.::|. .:|:||::.|||:|..|.:..|.|||....:..|   :...|.:.|:.|..|  |.:
  Rat   181 -CSISNP-DFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQR---KRILTRQNSQCISIRPGFPQ 240

  Fly   349 QRLTLRIH---------------RGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHH 398
            |...||:|               .|:..:.:|..:.........:.|..|||.:.
  Rat   241 QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQT---------- 295

  Fly   399 HDKIK--------ISVSYPSSENISELAGHGDVGHER-RQSGNALFAVHYN-----GTNGRESTE 449
            |..:|        .::.:||.|     .|.|....|| |.|.:...|...:     .:|||.||.
  Rat   296 HGGLKRYYSICQDTALRHPSLE-----GGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTS 355

  Fly   450 SQLYRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRME 514
            .:|...|.             :|:|                                     ..|
  Rat   356 LRLGPLQP-------------RGVP-------------------------------------LRE 370

  Fly   515 TKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQDC-VDPLLFSVLFWLGYCNSAVNPMIYALFSKD 578
            .||.:.:.|::|.||.||.|||..:::...||.| |.|.|:....||||.|||:||:||..|:.:
  Rat   371 KKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVE 435

  Fly   579 FRFAFKRII 587
            ||.||.:|:
  Rat   436 FRKAFLKIL 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	147/588 (25%)
		TM helix 1	22..48	CDD:320191	8/13 (62%)
		TM helix 2	55..81	CDD:320191	13/25 (52%)
		TM helix 3	93..123	CDD:320191	20/29 (69%)
		TM helix 4	135..158	CDD:320191	7/22 (32%)
		TM helix 5	292..321	CDD:320191	12/28 (43%)
		TM helix 6	512..542	CDD:320191	12/29 (41%)
		TM helix 7	551..576	CDD:320191	13/24 (54%)
Drd3	NP_058836.1	7tmA_D3_dopamine_R	30..440	CDD:320436	147/588 (25%)
		TM helix 1	31..57	CDD:320436	8/13 (62%)
		TM helix 2	64..87	CDD:320436	14/26 (54%)
		TM helix 3	103..133	CDD:320436	20/29 (69%)
		TM helix 4	150..168	CDD:320436	5/17 (29%)
		TM helix 5	185..210	CDD:320436	10/25 (40%)
		TM helix 6	368..398	CDD:320436	12/29 (41%)
		TM helix 7	408..433	CDD:320436	13/24 (54%)