Protein Alignment Oamb and Htr5a

DIOPT Version :9

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_037280.1
• Gene: Htr5a / 25689
• RGDID: 2851
• Length: 357
• Species: Rattus norvegicus
• Alignment Length: 598
• Identity: 119/598 - (19%)
• Similarity: 197/598 - (32%)
• Gaps: 273/598 - (45%)

  Fly     5 ECEDLIKSVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLV 69
            :.|.|..|..:.....::.|.:|.|:.......|.||:|.:........|.:..:.::|::|:||
  Rat    25 DTEALRTSQSFLSAFRVLVLTLLGFLAAATFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLV 89

  Fly    70 GLAVLPFSATWEVF-KVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMS 133
            .:.|:|.|...|:. :.|..|...|::|:|.||..|||||.|:.||:||||.::||.:.|
  Rat    90 AVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEY----- 149

  Fly   134 TKKAKSLIAGI-----WVLSFFICFPPLV-GWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLG 192
            |.:|:..::.:     |.||..|...||: ||
  Rat   150 TLRARKRVSNVMILLTWALSAVISLAPLLFGW--------------------------------- 181

  Fly   193 LDSIKDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSS 257
                                 |..|                                      |.
  Rat   182 ---------------------GETY--------------------------------------SE 187

  Fly   258 TTETEMDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAA 322
            .:|                         :|:::.:..|.::|.:|:||:|:.|:||.||:||:||
  Rat   188 LSE-------------------------ECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYKAA 227

  Fly   323 VRTTRAINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPER 387
                                  :|.           .||.:.:|:              :|.||.
  Rat   228 ----------------------KFR-----------MGSRKTNSV--------------SPIPEA 245

  Fly   388 LSKYATRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQL 452
            :            ::|.:..:|                      ..:|.|.:.....:  ||...
  Rat   246 V------------EVKDASQHP----------------------QMVFTVRHATVTFQ--TEGDT 274

  Fly   453 YRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKA 517
            :|:|:                                                        |.:|
  Rat   275 WREQK--------------------------------------------------------EQRA 283

  Fly   518 AKTLAIIVGMFIFCWCPFFTMYIIRPFCQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFA 582
            |..:.|::|:|:.||.|||...:|.|.|...:..|..|:..||||.||..||:||..|::.:..|
  Rat   284 ALMVGILIGVFVLCWFPFFVTELISPLCSWDIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSA 348

  Fly   583 FKRIICRCFCSRQ 595
            ||     .|.|:|
  Rat   349 FK-----VFFSKQ 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	42/130 (32%)
		7tm_1	37..>181	CDD:278431	45/150 (30%)
Htr5a	NP_037280.1	7tm_GPCRs	41..349	CDD:421689	110/568 (19%)
		TM helix 1	42..68	CDD:410628	7/25 (28%)
		TM helix 2	75..101	CDD:410628	7/25 (28%)
		TM helix 3	114..144	CDD:410628	17/29 (59%)
		TM helix 4	156..177	CDD:410628	4/20 (20%)
		TM helix 5	197..226	CDD:410628	13/28 (46%)
		TM helix 6	278..308	CDD:410628	12/85 (14%)
		TM helix 7	317..342	CDD:410628	12/24 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000