Protein Alignment Oamb and Htr1d

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_036984.1
• Gene: Htr1d / 25323
• RGDID: 2847
• Length: 374
• Species: Rattus norvegicus
• Alignment Length: 572
• Identity: 136/572 - (23%)
• Similarity: 199/572 - (34%)
• Gaps: 245/572 - (42%)

  Fly    22 ISL-AVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKV 85
            ||| .||..|.:..:..|..|:..:..:.||.:..|:.|.:||..||||.:.|:|.|..:...:.
  Rat    36 ISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRT 100

  Fly    86 WIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFF 150
            |.||.:.|.||::.|:..||||||:||.|:||||.|:|..:.|....:...|.::||.:|.:|..
  Rat   101 WNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISIC 165

  Fly   151 ICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGN 215
            |..|||. |:
  Rat   166 ISIPPLF-WR------------------------------------------------------- 174

  Fly   216 AYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTIS 280
                                                    .:|...||...|:|
  Rat   175 ----------------------------------------QATAHEEMSDCLVN----------- 188

  Fly   281 GSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSR 345
                     |:...|.:||..|:||||..:::..|.|||.||  .:|.:|.       ....|.|
  Rat   189 ---------TSQISYTIYSTCGAFYIPSILLIILYGRIYVAA--RSRILNP-------PSLYGKR 235

  Fly   346 FEEQRLTLRIHRGRGS---NQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVS 407
            |...:|   |....||   :...|:|     :|.|.|:|:|.             ..:::||.:
  Rat   236 FTTAQL---ITGSAGSSLCSLNPSLH-----ESHTHTVGSPL-------------FFNQVKIKL- 278

  Fly   408 YPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKG 472
                                                                             
  Rat   279 ----------------------------------------------------------------- 278

  Fly   473 LPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFT 537
                                  |:..:.|:.|.|     ..|.||.|||.||:|.||.||.|||.
  Rat   279 ----------------------ADSILERKRISA-----ARERKATKTLGIILGAFIICWLPFFV 316

  Fly   538 MYIIRPFCQD-C-VDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRII 587
            :.::.|.|:| | :.|.||....||||.||.:||:||.:|::|||.||:|::
  Rat   317 VSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVV 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	133/566 (23%)
		TM helix 1	22..48	CDD:320191	8/26 (31%)
		TM helix 2	55..81	CDD:320191	11/25 (44%)
		TM helix 3	93..123	CDD:320191	18/29 (62%)
		TM helix 4	135..158	CDD:320191	9/22 (41%)
		TM helix 5	292..321	CDD:320191	12/28 (43%)
		TM helix 6	512..542	CDD:320191	16/29 (55%)
		TM helix 7	551..576	CDD:320191	13/24 (54%)
Htr1d	NP_036984.1	7tmA_5-HT1B_1D	32..364	CDD:320455	133/566 (23%)
		TM helix 1	37..63	CDD:320455	7/25 (28%)
		TM helix 2	70..96	CDD:320455	11/25 (44%)
		TM helix 3	108..138	CDD:320455	18/29 (62%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	132..134		1/1 (100%)
		TM helix 4	150..173	CDD:320455	9/23 (39%)
		TM helix 5	191..220	CDD:320455	12/28 (43%)
		TM helix 6	291..321	CDD:320455	16/29 (55%)
		TM helix 7	332..357	CDD:320455	13/24 (54%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	349..353		2/3 (67%)