DRSC/TRiP Functional Genomics Resources

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Protein Alignment Oamb and Htr1a

DIOPT Version :9

Sequence 1:NP_001262774.1 Gene:Oamb / 43982 FlyBaseID:FBgn0024944 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_036717.1 Gene:Htr1a / 24473 RGDID:2845 Length:422 Species:Rattus norvegicus


Alignment Length:600 Identity:163/600 - (27%)
Similarity:248/600 - (41%) Gaps:216/600 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 EP----ANLISLAVLEF----INVLVIG--------GNCLVIAAVFCSNKLRSVTNFFIVNLAVA 65
            ||    .|:.|::.:.|    |..|::|        ||..|:||:.....|::|.|:.|.:|||.
  Rat    17 EPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVT 81

  Fly    66 DLLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPS 130
            ||:|.:.|||.:|.::|...|..|.:.|.:::|:||..||:|||:||||:||||.|:|.|:.|.:
  Rat    82 DLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVN 146

  Fly   131 IMSTKKAKSLIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDS 195
            ..:.::|.:||:..|::.|.|..||::||:                                   
  Rat   147 KRTPRRAAALISLTWLIGFLISIPPMLGWR----------------------------------- 176

  Fly   196 IKDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTE 260
                                                                             
  Rat   177 ----------------------------------------------------------------- 176

  Fly   261 TEMDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRT 325
                      .|::|      |.|..|.::.|.||.:||..|:||||:.:||..|.||:|||   
  Rat   177 ----------TPEDR------SDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAA--- 222

  Fly   326 TRAINQGFKTTKGSKGIGSRFEEQRLTLRIH-RGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLS 389
                               ||..::...::. :|.|                 |:|||.|     
  Rat   223 -------------------RFRIRKTVRKVEKKGAG-----------------TSLGTSS----- 246

  Fly   390 KYATRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNG--RESTESQL 452
                             :.|..::::...|.||   .||.:.|.  ||....|||  |:..:...
  Rat   247 -----------------APPPKKSLNGQPGSGD---WRRCAENR--AVGTPCTNGAVRQGDDEAT 289

  Fly   453 YRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVK-RFRMETK 516
            ....:.|.|.:|     .:.||       ..||:|.:.::....::...||.:|:.| ....|.|
  Rat   290 LEVIEVHRVGNS-----KEHLP-------LPSESGSNSYAPACLERKNERNAEAKRKMALARERK 342

  Fly   517 AAKTLAIIVGMFIFCWCPFFTMYIIRPFCQ-DCVDP-LLFSVLFWLGYCNSAVNPMIYALFSKDF 579
            ..|||.||:|.||.||.|||.:.::.|||: .|..| ||.:::.||||.||.:||:|||.|:|||
  Rat   343 TVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDF 407

  Fly   580 RFAFKRIICRCFCSR 594
            :.|||:||...||.|
  Rat   408 QNAFKKIIKCKFCRR 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OambNP_001262774.1 7tm_4 29..>154 CDD:304433 53/136 (39%)
7tm_1 37..>181 CDD:278431 53/143 (37%)
Htr1aNP_036717.1 7tm_4 48..>169 CDD:304433 49/120 (41%)
7tm_1 53..400 CDD:278431 140/540 (26%)
Agonist binding. /evidence=ECO:0000250 112..121 3/8 (38%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 133..135 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..261 9/64 (14%)
Agonist binding. /evidence=ECO:0000250 358..362 2/3 (67%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 396..400 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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