DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oamb and Adra1b

DIOPT Version :9

Sequence 1:	NP_001262774.1	Gene:	Oamb / 43982	FlyBaseID:	FBgn0024944	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_058687.2	Gene:	Adra1b / 24173	RGDID:	2054	Length:	515	Species:	Rattus norvegicus

Alignment Length:	759	Identity:	198/759 - (26%)
Similarity:	261/759 - (34%)	Gaps:	345/759 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IKSVKWTEP------ANLISLAVLEFINV-LVIG--------GNCLVIAAVFCSNKLRSVTNFFI 59
            :|...:|.|      :.|..|.|...|:| ||:|        ||.|||.:|.|:..||:.||:||
  Rat    20 LKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFI 84

  Fly    60 VNLAVADLLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTR 124
            ||||:||||:...|||||||.||...|:.|.::|.||.||||..||||||:|||||:|||:.|..
  Rat    85 VNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRY 149

  Fly   125 PVTYPSIMSTKKAKSLIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDG 189
            .:.||::::.:||...:..:||||..|...||:|||:.
  Rat   150 SLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEP--------------------------- 187

  Fly   190 QLGLDSIKDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTAS 254
                                               ||.|..
  Rat   188 -----------------------------------APNDDK------------------------ 193

  Fly   255 SSSTTETEMDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIY 319
                                           :|.:|.:..|.|:|:|||||||:.|:|..|.|:|
  Rat   194 -------------------------------ECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVY 227

  Fly   320 RAAVRTTRAINQG-FKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTP 383
            ..|.|||:.:..| .|....||         .||||||
  Rat   228 IVAKRTTKNLEAGVMKEMSNSK---------ELTLRIH--------------------------- 256

  Fly   384 SPERLSKYATRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGREST 448
                                       |:|..|               :.|.:....|.|.|.|.
  Rat   257 ---------------------------SKNFHE---------------DTLSSTKAKGHNPRSSI 279

  Fly   449 ESQLYRQQQQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRM 513
            ..:|:                                                        :|..
  Rat   280 AVKLF--------------------------------------------------------KFSR 288

  Fly   514 ETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFCQDCVDP-LLFSVLFWLGYCNSAVNPMIYALFSK 577
            |.||||||.|:|||||.||.|||....:.........| .:|.|:|||||.||.:||:||...||
  Rat   289 EKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSK 353

  Fly   578 DFRFAFKRII-CRCFCSRQSVSLKSSRRGSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMS 641
            :|:.||.||: |:|             ||.     |.|.|...:  ...|:::
  Rat   354 EFKRAFMRILGCQC-------------RGG-----RRRRRRRRL--GGCAYTY------------ 386

  Fly   642 NDPRXRSFGPSSSSQSSLGGLRKTSLKVPVYEICHPLVMETACYSYVEATSDGSASC-------- 698
             .|..|. |....|||     ||.||                         |.|.||
  Rat   387 -RPWTRG-GSLERSQS-----RKDSL-------------------------DDSGSCMSGSQRTL 419

  Fly   699 SVAGGNGGSVPKRTQLXPRELMALRGTRTGV---IPLPAGQRPR 739
            ..|..:.|.:.:.|| .|.||.|....:.|.   :|.|.|:|.|
  Rat   420 PSASPSPGYLGRGTQ-PPVELCAFPEWKPGALLSLPEPPGRRGR 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	68/133 (51%)
Oamb	NP_001262774.1	7tm_1	37..>181	CDD:278431	68/143 (48%)
Adra1b	NP_058687.2	7tmA_alpha1B_AR	46..359	CDD:320449	152/563 (27%)
		TM helix 1	48..72	CDD:320449	10/23 (43%)
		TM helix 2	81..103	CDD:320449	15/21 (71%)
		TM helix 3	119..141	CDD:320449	16/21 (76%)
		TM helix 4	164..180	CDD:320449	5/15 (33%)
		TM helix 5	201..224	CDD:320449	12/22 (55%)
		TM helix 6	293..315	CDD:320449	15/21 (71%)
		TM helix 7	327..352	CDD:320449	13/24 (54%)
		Nuclear localization signal. /evidence=ECO:0000250	368..378		5/14 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..430		14/68 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2726
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1095345at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.060