Protein Alignment Oamb and GPR161

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_001254538.1
• Gene: GPR161 / 23432
• HGNCID: 23694
• Length: 549
• Species: Homo sapiens
• Alignment Length: 769
• Identity: 137/769 - (17%)
• Similarity: 225/769 - (29%)
• Gaps: 324/769 - (42%)

  Fly    26 VLEFINVLVIG-----GNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKV 85
            :.:||.::||.     ||.:::..::..:.|.:::|.|:.:|.:::.|:.:.||||..|..:.:.
Human    48 ITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNFLLSVLVLPFVVTSSIRRE 112

  Fly    86 WIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFF 150
            ||||.:||.....:.:.:.:||:|.|..|::|||.||..|:.||..::..:|...:..||:.|..
Human   113 WIFGVVWCNFSALLYLLISSASMLTLGVIAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLI 177

  Fly   151 ICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGN 215
            .|.|||.||                        ||.|     .|..|
Human   178 GCLPPLFGW------------------------SSVE-----FDEFK------------------ 195

  Fly   216 AYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTIS 280
                                                                             
Human   196 ----------------------------------------------------------------- 195

  Fly   281 GSCPWKCELT--NDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIG 343
                |.|...  .:.||..:..:.....|..|||..|..|:|.|....|
Human   196 ----WMCVAAWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKAR---------------- 240

  Fly   344 SRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSY 408
                      ::|.|.....::.....|...|:|:|         |...:||
Human   241 ----------KVHCGTVVIVEEDAQRTGRKNSSTST---------SSSGSRR------------- 273

  Fly   409 PSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGL 473
                                   ||...|.|:                     |:.|
Human   274 -----------------------NAFQGVVYS---------------------ANQC-------- 286

  Fly   474 PELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTM 538
                                                      ||..|:.:::|.|:..|.|:  |
Human   287 ------------------------------------------KALITILVVLGAFMVTWGPY--M 307

  Fly   539 YIIRP---FCQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSR-QSVSL 599
            .:|..   :.:..|.|.|.:...||.:.::..:|:||.|::|..|   |.::..||..| .....
Human   308 VVIASEALWGKSSVSPSLETWATWLSFASAVCHPLIYGLWNKTVR---KELLGMCFGDRYYREPF 369

  Fly   600 KSSRRGSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMSND--------------------- 643
            ...:|.|.:.:|..|.....::|...|...|.: .|.||..:.|
Human   370 VQRQRTSRLFSISNRITDLGLSPHLTALMAGGQ-PLGHSSSTGDTGFSCSQDSGTDMMLLEDYTS 433

  Fly   644 -----------PRXRSFGPSSSSQSSLGGLRKTSL---KVPVYE--------ICHPLVMETACYS 686
                       |: ||..........:....|.|:   |..|::        :...:..|.....
Human   434 DDNPPSHCTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINL 498

  Fly   687 YVEATSDG---SASCSVAGGNGGSVPKRTQLXPRELMALRGTRTGVIPLPAGQR 737
            :.|....|   :|.....||.||....||.: .|  :.|:....|.: |.|.||
Human   499 FGEEALPGVLVTARTVPGGGFGGRRGSRTLVSQR--LQLQSIEEGDV-LAAEQR 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	98/566 (17%)
		TM helix 1	22..48	CDD:320191	6/26 (23%)
		TM helix 2	55..81	CDD:320191	9/25 (36%)
		TM helix 3	93..123	CDD:320191	10/29 (34%)
		TM helix 4	135..158	CDD:320191	8/22 (36%)
		TM helix 5	292..321	CDD:320191	8/28 (29%)
		TM helix 6	512..542	CDD:320191	8/29 (28%)
		TM helix 7	551..576	CDD:320191	8/24 (33%)
GPR161	NP_001254538.1	7tmA_GPR161	49..355	CDD:320342	99/568 (17%)
		TM helix 1	49..75	CDD:320342	6/25 (24%)
		TM helix 2	82..107	CDD:320342	8/24 (33%)
		TM helix 3	120..150	CDD:320342	10/29 (34%)
		TM helix 4	162..184	CDD:320342	7/21 (33%)
		TM helix 5	205..234	CDD:320342	8/28 (29%)
		TM helix 6	283..313	CDD:320342	11/81 (14%)
		TM helix 7	323..348	CDD:320342	8/24 (33%)