Protein Alignment Oamb and DRD1

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_000785.1
• Gene: DRD1 / 1812
• HGNCID: 3020
• Length: 446
• Species: Homo sapiens
• Alignment Length: 645
• Identity: 156/645 - (24%)
• Similarity: 221/645 - (34%)
• Gaps: 290/645 - (44%)

  Fly    29 FINVLVIG---GNCLVIAAVFCSNKLRS-VTNFFIVNLAVADLLVGLAVLPFSATWEVFKVWIFG 89
            |:::|::.   ||.||.|||.....||| |||||:::|||:||||.:.|:|:.|..|:...|.||
Human    29 FLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG 93

  Fly    90 DLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFICFP 154
            . :|.||:|.|:...||||||||.||:|||.|::.|..|...|:.|.|..||:..|.||..|.|.
Human    94 S-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFI 157

  Fly   155 PL-VGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNAYN 218
            |: :.|...|    ||
Human   158 PVQLSWHKAK----PT------------------------------------------------- 169

  Fly   219 PYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISGSC 283
                  :|.||:|......||:
Human   170 ------SPSDGNATSLAETIDN------------------------------------------- 185

  Fly   284 PWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSRFEE 348
               |:.:..|.|.:.|::.|||||:.:|:..|.||||.|.:..|.|
Human   186 ---CDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRI------------------- 228

  Fly   349 QRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPSSEN 413
                                                                             
Human   229 ----------------------------------------------------------------- 228

  Fly   414 ISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGLP-ELA 477
                     ...||.       |||                       |.:|....|.|.| |.:
Human   229 ---------AALERA-------AVH-----------------------AKNCQTTTGNGKPVECS 254

  Fly   478 RRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIR 542
            :.:|:.              ||.          |:.|||..|||::|:|:|:.||.|||.:..|.
Human   255 QPESSF--------------KMS----------FKRETKVLKTLSVIMGVFVCCWLPFFILNCIL 295

  Fly   543 PFCQD------CVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRII-CRCFC-----SRQ 595
            |||..      |:|...|.|..|.|:.||::||:||| |:.|||.||..:: |...|     :.:
Human   296 PFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLLGCYRLCPATNNAIE 359

  Fly   596 SVSLKSS----------RRGSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMSNDPR 645
            :||:.::          .|||......:....|        |:.|...:|...|.:...|
Human   360 TVSINNNGAAMFSSHHEPRGSISKECNLVYLIP--------HAVGSSEDLKKEEAAGIAR 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	141/565 (25%)
		TM helix 1	22..48	CDD:320191	9/21 (43%)
		TM helix 2	55..81	CDD:320191	14/25 (56%)
		TM helix 3	93..123	CDD:320191	19/29 (66%)
		TM helix 4	135..158	CDD:320191	10/23 (43%)
		TM helix 5	292..321	CDD:320191	13/28 (46%)
		TM helix 6	512..542	CDD:320191	14/29 (48%)
		TM helix 7	551..576	CDD:320191	11/24 (46%)
DRD1	NP_000785.1	7tmA_D1A_dopamine_R	23..341	CDD:320443	141/565 (25%)
		TM helix 1	25..51	CDD:320443	9/21 (43%)
		TM helix 2	59..86	CDD:320443	14/26 (54%)
		TM helix 3	96..126	CDD:320443	19/29 (66%)
		TM helix 4	138..161	CDD:320443	10/22 (45%)
		TM helix 5	191..221	CDD:320443	14/29 (48%)
		TM helix 6	265..295	CDD:320443	14/29 (48%)
		TM helix 7	310..335	CDD:320443	12/25 (48%)