Protein Alignment Oamb and Htr1f

DIOPT Version :9

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_032336.1
• Gene: Htr1f / 15557
• MGIID: 99842
• Length: 366
• Species: Mus musculus
• Alignment Length: 586
• Identity: 135/586 - (23%)
• Similarity: 211/586 - (36%)
• Gaps: 237/586 - (40%)

  Fly     7 EDLIKSVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGL 71
            |:|:..:    |:.::....|..:.::....|.|||||:..:.||....|:.|.:|||.|.||.:
Mouse    14 EELLNRM----PSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAV 74

  Fly    72 AVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKK 136
            .|:|||..:.|.:.||.|.:.|.|||:||:..||.|||:|.||:||||.|:|..|.|....:.:.
Mouse    75 LVMPFSIVYIVRESWIMGQVLCDIWLSVDIICCTCSILHLSAIALDRYRAITDAVEYARKRTPRH 139

  Fly   137 AKSLIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGE 201
            |..:|..:||:|.||..|||. |:.|                     .:|.|.:
Mouse   140 AGIMITIVWVISVFISMPPLF-WRHQ---------------------GTSRDDE----------- 171

  Fly   202 ASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLD 266
                                                                             
Mouse   172 ----------------------------------------------------------------- 171

  Fly   267 LLNAPPQNRPQTISGSCPWKCELTNDR-GYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAIN 330
                                |.:.:|. ...:||..|:||||:.::|..|::|||||
Mouse   172 --------------------CVIKHDHIVSTIYSTFGAFYIPLVLILILYYKIYRAA-------- 208

  Fly   331 QGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRR 395
                .|...|...||..::.|..::....|   :.|:....::.....:|..||.:
Mouse   209 ----RTLYHKRQASRMIKEELNGQVFLESG---EKSIKLVSTSYMLEKSLSDPSTD--------- 257

  Fly   396 LHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHG 460
               .|:|..:|..|.||          :.||:.                        :|:|:..|
Mouse   258 ---FDRIHSTVKSPRSE----------LKHEKS------------------------WRRQKISG 285

  Fly   461 VASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIV 525
            .                                                   .|.|||.||.:|:
Mouse   286 T---------------------------------------------------RERKAATTLGLIL 299

  Fly   526 GMFIFCWCPFFTMYIIRPFCQDC-VDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRII-C 588
            |.|:.||.|||...::...|:.| :...:.:.|.||||.||.:||:||.:|::||:.||:::: |
Mouse   300 GAFVICWLPFFVKELVVNVCEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRC 364

  Fly   589 R 589
            |
Mouse   365 R 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	53/124 (43%)
		7tm_1	37..>181	CDD:278431	58/143 (41%)
Htr1f	NP_032336.1	7tm_4	33..>155	CDD:304433	52/121 (43%)
		7tm_1	41..347	CDD:278431	122/535 (23%)
		Agonist binding. /evidence=ECO:0000250	99..108		4/8 (50%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250	120..122		1/1 (100%)
		Agonist binding. /evidence=ECO:0000250	306..310		2/3 (67%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250	343..347		2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910