DRSC/TRiP Functional Genomics Resources

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Protein Alignment Oamb and Htr1d

DIOPT Version :9

Sequence 1:NP_001262774.1 Gene:Oamb / 43982 FlyBaseID:FBgn0024944 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001272411.1 Gene:Htr1d / 15552 MGIID:96276 Length:374 Species:Mus musculus


Alignment Length:572 Identity:135/572 - (23%)
Similarity:200/572 - (34%) Gaps:245/572 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 ISL-AVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKV 85
            ||| .||..|.:..:..|..|:..:..:.||.:..|:.|.:||..||||.:.|:|.|..:...:.
Mouse    36 ISLVVVLSVITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRT 100

  Fly    86 WIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFF 150
            |.||.:.|.||::.|:..||||||:||.|:||||.|:|..:.|....:...|.::||.:|::|..
Mouse   101 WNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISIC 165

  Fly   151 ICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGN 215
            |..|||. |:                                                       
Mouse   166 ISIPPLF-WR------------------------------------------------------- 174

  Fly   216 AYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTIS 280
                                                    .:|...||...|:|           
Mouse   175 ----------------------------------------QATAHEEMSDCLVN----------- 188

  Fly   281 GSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSR 345
                     |:...|.:||..|:||||..:::..|.|||.||  .:|.:|.       ....|.|
Mouse   189 ---------TSQISYTIYSTCGAFYIPSILLIILYGRIYVAA--RSRILNP-------PSLYGKR 235

  Fly   346 FEEQRLTLRIHRGRGS---NQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVS 407
            |...:|   |....||   :...|:|     :|.|.|:|:|.             ..:::||.: 
Mouse   236 FTTAQL---ITGSAGSSLCSLNPSLH-----ESHTHTVGSPL-------------FFNQVKIKL- 278

  Fly   408 YPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKG 472
                                                                             
Mouse   279 ----------------------------------------------------------------- 278

  Fly   473 LPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFT 537
                                  |:..:.|:.|.|     ..|.||.|||.||:|.||.||.|||.
Mouse   279 ----------------------ADSILERKRISA-----ARERKATKTLGIILGAFIICWLPFFV 316

  Fly   538 MYIIRPFCQD-C-VDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRII 587
            :.::.|.|:| | :.|.||....||||.||.:||:||.:|::|||.||::::
Mouse   317 VSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQKVV 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OambNP_001262774.1 7tm_4 29..>154 CDD:304433 45/124 (36%)
7tm_1 37..>181 CDD:278431 48/143 (34%)
Htr1dNP_001272411.1 7tm_GPCRs 32..364 CDD:391938 133/566 (23%)
TM helix 1 38..62 CDD:341315 6/23 (26%)
TM helix 2 71..93 CDD:341315 10/21 (48%)
TM helix 3 109..131 CDD:341315 12/21 (57%)
Agonist binding. /evidence=ECO:0000250 111..120 2/8 (25%)
DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250 132..134 1/1 (100%)
TM helix 4 154..170 CDD:341315 5/15 (33%)
TM helix 5 192..215 CDD:341315 8/22 (36%)
TM helix 6 294..319 CDD:341315 15/24 (63%)
Agonist binding. /evidence=ECO:0000250 311..315 2/3 (67%)
TM helix 7 332..357 CDD:341315 13/24 (54%)
NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250 349..353 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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