Protein Alignment Oamb and ADRB3

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_000016.1
• Gene: ADRB3 / 155
• HGNCID: 288
• Length: 408
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 144/613 - (23%)
• Similarity: 210/613 - (34%)
• Gaps: 271/613 - (44%)

  Fly    21 LISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKV 85
            |::||||     ..:|||.|||.|:..:.:|:::||.|:.:||.|||::||.|:|.:||..:...
Human    43 LLALAVL-----ATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH 102

  Fly    86 WIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFF 150
            |..|...|.:|.:|||...||||..|||:::|||:|||.|:.|.::::.:.|::.:..:||:|..
Human   103 WPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAA 167

  Fly   151 ICFPPLVG--WKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGN 213
            :.|.|::.  |:                              :|.|:     ||....|.|.
Human   168 VSFAPIMSQWWR------------------------------VGADA-----EAQRCHSNPR--- 194

  Fly   214 GNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQT 278
                                                                             
Human   195 ----------------------------------------------------------------- 194

  Fly   279 ISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIG 343
                |   |...::..|||.|:..|||:|:.||||.|.|::..|.|
Human   195 ----C---CAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATR------------------- 233

  Fly   344 SRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSY 408
                    .||:.||.                    ||...||......:|.|
Human   234 --------QLRLLRGE--------------------LGRFPPEESPPAPSRSL------------ 258

  Fly   409 PSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGL 473
                      ....||                                       :|  ...:|:
Human   259 ----------APAPVG---------------------------------------TC--APPEGV 272

  Fly   474 PELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTM 538
            |...||                         .|::...| |.:|..||.:|:|.|..||.|||..
Human   273 PACGRR-------------------------PARLLPLR-EHRALCTLGLIMGTFTLCWLPFFLA 311

  Fly   539 YIIRPFCQDCVDP-LLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSVSLKSS 602
            .::|......:.| ..|..|.||||.|||.||:||.. |.|||.||:|::|||
Human   312 NVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCR-SPDFRSAFRRLLCRC------------ 363

  Fly   603 RRGSDMSAIRIRARTPSITPSA--AAHS 628
              |..:......|..|::.||.  ||.|
Human   364 --GRRLPPEPCAAARPALFPSGVPAARS 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	130/564 (23%)
		TM helix 1	22..48	CDD:320191	11/25 (44%)
		TM helix 2	55..81	CDD:320191	14/25 (56%)
		TM helix 3	93..123	CDD:320191	16/29 (55%)
		TM helix 4	135..158	CDD:320191	6/22 (27%)
		TM helix 5	292..321	CDD:320191	14/28 (50%)
		TM helix 6	512..542	CDD:320191	13/29 (45%)
		TM helix 7	551..576	CDD:320191	14/25 (56%)
ADRB3	NP_000016.1	7tm_GPCRs	51..356	CDD:475119	125/551 (23%)
		TM helix 2	73..95	CDD:320625	11/21 (52%)
		TM helix 3	111..133	CDD:320625	11/21 (52%)
		TM helix 4	156..172	CDD:320625	4/15 (27%)
		TM helix 5	202..225	CDD:320625	12/22 (55%)
		TM helix 6	291..313	CDD:320625	10/21 (48%)
		TM helix 7	325..350	CDD:320625	13/25 (52%)