Protein Alignment Oamb and ADRB1

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_000675.1
• Gene: ADRB1 / 153
• HGNCID: 285
• Length: 477
• Species: Homo sapiens
• Alignment Length: 668
• Identity: 155/668 - (23%)
• Similarity: 237/668 - (35%)
• Gaps: 254/668 - (38%)

  Fly    12 SVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPF 76
            |.:||....|:    :..|.:|::.||.|||.|:..:.:|:::||.||::||.|||::||.|:||
Human    54 SQQWTAGMGLL----MALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPF 114

  Fly    77 SATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLI 141
            .||..|:..|.:|..:|.:|.:|||...||||..||.|:||||:|:|.|..|.|:::..:|:.|:
Human   115 GATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLV 179

  Fly   142 AGIWVLSFFICFPPLV--GWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASL 204
            ..:|.:|..:.|.|::  .|:                       :.|::.:
Human   180 CTVWAISALVSFLPILMHWWR-----------------------AESDEAR-------------- 207

  Fly   205 PPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLN 269
                      ..||  ||
Human   208 ----------RCYN--DP----------------------------------------------- 213

  Fly   270 APPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFK 334
                        .|   |:...:|.|.:.|::.|||:|:.:|.|.|.|::|.|.:..:.|:..
Human   214 ------------KC---CDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSC-- 261

  Fly   335 TTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHH 399
                         |:|..       |...:....|.....:.....|.|.|...:  ||..|
Human   262 -------------ERRFL-------GGPARPPSPSPSPVPAPAPPPGPPRPAAAA--ATAPL--- 301

  Fly   400 DKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASS 464
                                                      .|||
Human   302 ------------------------------------------ANGR------------------- 305

  Fly   465 CYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFI 529
                                    :|..||:.....|            |.||.|||.||:|:|.
Human   306 ------------------------AGKRRPSRLVALR------------EQKALKTLGIIMGVFT 334

  Fly   530 FCWCPFFTMYIIRPFCQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSR 594
            .||.|||...:::.|.::.|...||....||||.|||.||:||.. |.|||.||:.::|   |:|
Human   335 LCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQGLLC---CAR 395

  Fly   595 QSVSLKSSRRGSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMSNDPRXRSFGPSSSSQSSL 659
            ::...:.:..|....|....|| |...||..|.|..|:.::    :...|. |...|.:......
Human   396 RAARRRHATHGDRPRASGCLAR-PGPPPSPGAASDDDDDDV----VGATPPARLLEPWAGCNGGA 455

  Fly   660 GGLRKTSLKVPVYEICHP 677
            .....:||..|    |.|
Human   456 AADSDSSLDEP----CRP 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	129/563 (23%)
		TM helix 1	22..48	CDD:320191	8/25 (32%)
		TM helix 2	55..81	CDD:320191	16/25 (64%)
		TM helix 3	93..123	CDD:320191	17/29 (59%)
		TM helix 4	135..158	CDD:320191	6/24 (25%)
		TM helix 5	292..321	CDD:320191	11/28 (39%)
		TM helix 6	512..542	CDD:320191	15/29 (52%)
		TM helix 7	551..576	CDD:320191	13/24 (54%)
ADRB1	NP_000675.1	7tmA_Beta1_AR	59..387	CDD:320624	129/567 (23%)
		TM helix 1	60..86	CDD:320624	9/29 (31%)
		TM helix 2	93..120	CDD:320624	16/26 (62%)
		TM helix 3	131..161	CDD:320624	17/29 (59%)
		TM helix 4	175..193	CDD:320624	5/17 (29%)
		TM helix 5	221..253	CDD:320624	13/31 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..307		10/127 (8%)
		TM helix 6	317..347	CDD:320624	16/41 (39%)
		TM helix 7	356..381	CDD:320624	13/25 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	403..477		18/76 (24%)
		PDZ-Binding	474..477