Protein Alignment Oamb and ADRA2B

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_000673.2
• Gene: ADRA2B / 151
• HGNCID: 282
• Length: 450
• Species: Homo sapiens
• Alignment Length: 592
• Identity: 158/592 - (26%)
• Similarity: 238/592 - (40%)
• Gaps: 192/592 - (32%)

  Fly    25 AVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKVWIFG 89
            |.:.|:.:..|.||.|||.||..|..||:..|.|:|:||.||:||...::|||...|:...|.|.
Human    17 AAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFR 81

  Fly    90 DLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFICFP 154
            ..||.::||:||..||:||::|||||||||.||:|.:.|.|..:.::.|.:|..:|:::..|..|
Human    82 RTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLP 146

  Fly   155 PLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNAYNP 219
            ||:            | ||                        |||
Human   147 PLI------------Y-KG------------------------DQG------------------- 155

  Fly   220 YDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISGSCP 284
                                                              ..|:.|||
Human   156 --------------------------------------------------PQPRGRPQ------- 163

  Fly   285 WKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSRFEEQ 349
              |:|..:..|:|.|::|||:.|..:|:..|.|||..|.|:.|         :|.:..|.
Human   164 --CKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNR---------RGPRAKGG----- 212

  Fly   350 RLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPSSENI 414
                   .|:|.::|......|:..|...      |...|..:.|.::.|
Human   213 -------PGQGESKQPRPDHGGALASAKL------PALASVASAREVNGH--------------- 249

  Fly   415 SELAGHGDVGHERRQSGNALF-----AVHYNGTNGRE-----STESQLYRQQQQH---------- 459
            |:..|..:.|.....:|....     |:..:|...:|     |.|.:...::::.
Human   250 SKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQA 314

  Fly   460 ---GVASSCY--LQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAK 519
               ..||:|.  ||..:|...||..:.......|.|   ....:..||  :||:.|   |.:...
Human   315 VPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVG---AIGGQWWRR--RAQLTR---EKRFTF 371

  Fly   520 TLAIIVGMFIFCWCPFFTMYIIRPFC-QDCVDPL-LFSVLFWLGYCNSAVNPMIYALFSKDFRFA 582
            .||:::|:|:.||.|||..|.:...| :.|..|. ||...||:|||||::||:||.:|::|||.|
Human   372 VLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRA 436

  Fly   583 FKRIICR 589
            |:||:||
Human   437 FRRILCR 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	152/584 (26%)
		TM helix 1	22..48	CDD:320191	10/22 (45%)
		TM helix 2	55..81	CDD:320191	12/25 (48%)
		TM helix 3	93..123	CDD:320191	19/29 (66%)
		TM helix 4	135..158	CDD:320191	7/22 (32%)
		TM helix 5	292..321	CDD:320191	12/28 (43%)
		TM helix 6	512..542	CDD:320191	11/29 (38%)
		TM helix 7	551..576	CDD:320191	14/25 (56%)
ADRA2B	NP_000673.2	7tmA_alpha2B_AR	7..437	CDD:320444	152/584 (26%)
		TM helix 1	14..40	CDD:320444	10/22 (45%)
		TM helix 2	47..73	CDD:320444	12/25 (48%)
		TM helix 3	85..115	CDD:320444	19/29 (66%)
		TM helix 4	127..150	CDD:320444	7/34 (21%)
		TM helix 5	169..198	CDD:320444	12/28 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..229		7/45 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..329		15/102 (15%)
		TM helix 6	364..394	CDD:320444	12/32 (38%)
		TM helix 7	405..430	CDD:320444	13/24 (54%)