DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oamb and ADRA1D

DIOPT Version :9

Sequence 1:	NP_001262774.1	Gene:	Oamb / 43982	FlyBaseID:	FBgn0024944	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_000669.1	Gene:	ADRA1D / 146	HGNCID:	280	Length:	572	Species:	Homo sapiens

Alignment Length:	718	Identity:	186/718 - (25%)
Similarity:	263/718 - (36%)	Gaps:	301/718 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKVW 86
            :.:.:..|| ::.:.||.|||.:|.|:..|::|||:|||||||||||:...|||||||.||...|
Human    99 VGVFLAAFI-LMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFW 162

  Fly    87 IFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFI 151
            .||..:|.:|.||||..||||||:||.||:||||.|...:.||:||:.:||.:::|.:||::..:
Human   163 AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVV 227

  Fly   152 CFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNA 216
            ...||:|||:                                            |.||
Human   228 SVGPLLGWKE--------------------------------------------PVPP------- 241

  Fly   217 YNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISG 281
                |..|
Human   242 ----DERF--------------------------------------------------------- 245

  Fly   282 SCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSRF 346
                 |.:|.:.||.::|::.|||:||.|::..|.|:|..|..|||::..|.|..:|
Human   246 -----CGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERG-------- 297

  Fly   347 EEQRLTLRIH-RGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPS 410
            :...:.|||| ||..:
Human   298 KASEVVLRIHCRGAAT------------------------------------------------- 313

  Fly   411 SENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGLPE 475
                                          |.:|             .||:.|:
Human   314 ------------------------------GADG-------------AHGMRSA----------- 324

  Fly   476 LARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYI 540
                         .||:       .|.::..::.:|..|.||||||||:||:|:.||.|||   .
Human   325 -------------KGHT-------FRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFF---F 366

  Fly   541 IRP----FCQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICRCFCSRQSVSLKS 601
            :.|    |.|......:|.|:|||||.||.|||:||...|::|:.||.|:: ||.|.|:
Human   367 VLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLL-RCQCRRR------ 424

  Fly   602 SRRGSDMSAI---RIRARTPSITPSAAAHSFG---------------DESELHHSEMSNDPRXRS 648
             ||...:..:   ..||.|..:....|..|..               |.......||..... |.
Human   425 -RRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRR 488

  Fly   649 FGPSSSSQ-SSLGGLRK--TSLKVPVYEICHPL------VMETAC--YSYVEATSDG-------S 695
            ..||:..: ..||..|:  |.|:..|..:.|.:      ..|.||  .|.|||.|.|       .
Human   489 KPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEG 553

  Fly   696 ASC 698
            |:|
Human   554 ATC 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	66/124 (53%)
Oamb	NP_001262774.1	7tm_1	37..>181	CDD:278431	69/143 (48%)
ADRA1D	NP_000669.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		7tmA_alpha1D_AR	97..413	CDD:320450	148/565 (26%)
		TM helix 1	98..124	CDD:320450	8/25 (32%)
		TM helix 2	131..157	CDD:320450	20/25 (80%)
		TM helix 3	169..199	CDD:320450	20/29 (69%)
		TM helix 4	211..234	CDD:320450	7/22 (32%)
		TM helix 5	251..280	CDD:320450	12/28 (43%)
		TM helix 6	341..371	CDD:320450	18/32 (56%)
		TM helix 7	381..406	CDD:320450	14/24 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..488		5/43 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1095345at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920