Protein Alignment Oamb and Drd5

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_038531.1
• Gene: Drd5 / 13492
• MGIID: 94927
• Length: 478
• Species: Mus musculus
• Alignment Length: 654
• Identity: 154/654 - (23%)
• Similarity: 229/654 - (35%)
• Gaps: 280/654 - (42%)

  Fly    18 PANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRS-VTNFFIVNLAVADLLVGLAVLPFSATWE 81
            ||.:::..:|..:.|..:.||.||.||:..|..||: :||.|||:|||:||.|.|.|:|:.|..|
Mouse    36 PAQVVTAGLLTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAE 100

  Fly    82 VFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWV 146
            |...|.|| .:|.||:|.|:...||||||||.||:|||.|::||..|...|:.:.|..::|..|.
Mouse   101 VAGYWPFG-AFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVALAWT 164

  Fly   147 LSFFICFPPL-VGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPH 210
            ||..|.|.|: :.|...||                     ...|:.||.|.:
Mouse   165 LSILISFIPVQLNWHRDKA---------------------GSQGREGLLSNE------------- 195

  Fly   211 IGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNR 275
                   .|::.|: .:||..|
Mouse   196 -------TPWEEGW-ELDGRTE------------------------------------------- 209

  Fly   276 PQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSK 340
                      .|:.:.:|.|.:.|:|.|||||:.:|:..|.||||.|....|.|
Mouse   210 ----------NCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRI----------- 253

  Fly   341 GIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKIS 405
               |..|           |.:....|..|.|:.:        |.|
Mouse   254 ---SSLE-----------RAAEHAQSCRSRGACE--------PDP-------------------- 276

  Fly   406 VSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVG 470
                                                                             
Mouse   277 ----------------------------------------------------------------- 276

  Fly   471 KGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPF 535
                                            :::|.:|:   |||..|||::|:|:|:.||.||
Mouse   277 --------------------------------SLRASIKK---ETKVFKTLSVIMGVFVCCWLPF 306

  Fly   536 FTMYIIRPFCQD-----------CVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRII-C 588
            |.:..:.|||..           ||....|.:..|.|:.||::||:||| |:.|||..|.::: |
Mouse   307 FILNCMVPFCSSGDAQGPRTGFPCVSETTFDIFVWFGWANSSLNPIIYA-FNADFRKVFAQLLGC 370

  Fly   589 RCFCSR---QSVSLKSSRRGSDMSAI---RIRARTPSITPSAAA---HSFGDESEL-------HH 637
            ...|.|   |:|::.:.....:...:   .|.|....:.|:|.:   ...|:|.|.       |.
Mouse   371 SHLCFRTPVQTVNISNELISYNQDTVFHREIAAAYVHMIPNAVSSGDREVGEEEEAEEEGPFDHM 435

  Fly   638 SEMS 641
            |::|
Mouse   436 SQIS 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	136/574 (24%)
		TM helix 1	22..48	CDD:320191	8/25 (32%)
		TM helix 2	55..81	CDD:320191	15/25 (60%)
		TM helix 3	93..123	CDD:320191	19/29 (66%)
		TM helix 4	135..158	CDD:320191	8/23 (35%)
		TM helix 5	292..321	CDD:320191	14/28 (50%)
		TM helix 6	512..542	CDD:320191	14/29 (48%)
		TM helix 7	551..576	CDD:320191	10/24 (42%)
Drd5	NP_038531.1	7tm_GPCRs	39..364	CDD:475119	136/574 (24%)
		TM helix 1	41..65	CDD:410628	8/23 (35%)
		TM helix 2	75..97	CDD:410628	13/21 (62%)
		TM helix 3	112..134	CDD:410628	13/21 (62%)
		TM helix 4	157..173	CDD:410628	6/15 (40%)
		TM helix 5	217..240	CDD:410628	10/22 (45%)
		TM helix 6	289..311	CDD:410628	11/21 (52%)
		TM helix 7	333..358	CDD:410628	11/25 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	416..446		6/24 (25%)