Protein Alignment Oamb and Drd1

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_034206.1
• Gene: Drd1 / 13488
• MGIID: 99578
• Length: 446
• Species: Mus musculus
• Alignment Length: 646
• Identity: 156/646 - (24%)
• Similarity: 224/646 - (34%)
• Gaps: 291/646 - (45%)

  Fly    29 FINVLVIG---GNCLVIAAVFCSNKLRS-VTNFFIVNLAVADLLVGLAVLPFSATWEVFKVWIFG 89
            |:::|::.   ||.||.|||.....||| |||||:::|||:||||.:.|:|:.|..|:...|.||
Mouse    28 FLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG 92

  Fly    90 DLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFFICFP 154
            . :|.||:|.|:...||||||||.||:|||.|::.|..|...|:.|.|..||:..|.||..|.|.
Mouse    93 S-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFI 156

  Fly   155 PL-VGWKDQKAVIQPTYP-KGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGNAY 217
            |: :.|...|    ||:| .||.|        |.||.:
Mouse   157 PVQLSWHKAK----PTWPLDGNFT--------SLEDAE--------------------------- 182

  Fly   218 NPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTISGS 282
                      |.:.:.|::
Mouse   183 ----------DDNCDTRLS---------------------------------------------- 191

  Fly   283 CPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTKGSKGIGSRFE 347
                      |.|.:.|:|.|||||:.:|:..|..|||.|.:..|.|:
Mouse   192 ----------RTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRIS----------------- 229

  Fly   348 EQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKISVSYPSSE 412
                                                        |..|.
Mouse   230 --------------------------------------------ALERA---------------- 234

  Fly   413 NISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQVGKGLP-EL 476
                                   |||                       |.:|....|.|.| |.
Mouse   235 -----------------------AVH-----------------------AKNCQTTTGNGNPVEC 253

  Fly   477 ARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYII 541
            ::.:|:.              ||.          |:.|||..|||::|:|:|:.||.|||....:
Mouse   254 SQSESSF--------------KMS----------FKRETKVLKTLSVIMGVFVCCWLPFFISNCM 294

  Fly   542 RPFCQD------CVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRII-CRCFC-----SR 594
            .|||..      |:|.:.|.|..|.|:.||::||:||| |:.||:.||..:: |...|     :.
Mouse   295 VPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYA-FNADFQKAFSTLLGCYRLCPTTNNAI 358

  Fly   595 QSVSLKSS----------RRGSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMSNDPR 645
            ::||:.::          .|||......:....|        |:.|...:|...|....|:
Mouse   359 ETVSINNNGAVMFSSHHEPRGSISKDCNLVYLIP--------HAVGSSEDLKREEAGGIPK 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	141/566 (25%)
		TM helix 1	22..48	CDD:320191	9/21 (43%)
		TM helix 2	55..81	CDD:320191	14/25 (56%)
		TM helix 3	93..123	CDD:320191	19/29 (66%)
		TM helix 4	135..158	CDD:320191	10/23 (43%)
		TM helix 5	292..321	CDD:320191	13/28 (46%)
		TM helix 6	512..542	CDD:320191	14/29 (48%)
		TM helix 7	551..576	CDD:320191	11/24 (46%)
Drd1	NP_034206.1	7tm_GPCRs	22..341	CDD:475119	141/566 (25%)
		TM helix 1	25..49	CDD:410628	9/20 (45%)
		TM helix 2	59..81	CDD:410628	12/21 (57%)
		TM helix 3	96..118	CDD:410628	13/21 (62%)
		TM helix 4	141..157	CDD:410628	7/15 (47%)
		TM helix 5	192..215	CDD:410628	10/22 (45%)
		TM helix 6	271..293	CDD:410628	11/21 (52%)
		TM helix 7	310..335	CDD:410628	12/25 (48%)