Protein Alignment Oamb and TAAR9

DIOPT Version :10

• Sequence 1: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Sequence 2: NP_778227.3
• Gene: TAAR9 / 134860
• HGNCID: 20977
• Length: 348
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 122/582 - (20%)
• Similarity: 182/582 - (31%)
• Gaps: 276/582 - (47%)

  Fly     7 EDLIKSVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGL 71
            |..||:.....|.::: .|||.|..||...||.||:.|:....:|.:.|||.|.:||.||.|||:
Human    20 ESCIKTPYSPGPRSIL-YAVLGFGAVLAAFGNLLVMIAILHFKQLHTPTNFLIASLACADFLVGV 83

  Fly    72 AVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKK 136
            .|:|||....|...|.|||.:|:.....|...|.||:.:||.||:|||:|||.|:|||    ||.
Human    84 TVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCFASLFHLCCISVDRYIAVTDPLTYP----TKF 144

  Fly   137 AKSLIAGIW-VLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQG 200
            ..| ::||. |||:|               ...||   :.:::||   .::|:|
Human   145 TVS-VSGICIVLSWF---------------FSVTY---SFSIFYT---GANEEG----------- 176

  Fly   201 EASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDL 265
                                          .|..:.|:
Human   177 ------------------------------IEELVVAL--------------------------- 184

  Fly   266 DLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAIN 330
                            :|...|:...::.:||...| .|:||...|:|.|.:|:..|
Human   185 ----------------TCVGGCQAPLNQNWVLLCFL-LFFIPNVAMVFIYSKIFLVA-------- 224

  Fly   331 QGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRR 395
                                                                       |:..|:
Human   225 -----------------------------------------------------------KHQARK 230

  Fly   396 LHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHG 460
            :                                                 |||.||.....:.:
Human   231 I-------------------------------------------------ESTASQAQSSSESY- 245

  Fly   461 VASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTLAIIV 525
                                               .:::.:|           |.||||||.|.:
Human   246 -----------------------------------KERVAKR-----------ERKAAKTLGIAM 264

  Fly   526 GMFIFCWCPFFTMYIIRPFCQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRII 587
            ..|:..|.|:....:|..:......|.::.:|.|..|.|||:||:|||.|.:.|..|.|.|:
Human   265 AAFLVSWLPYLVDAVIDAYMNFITPPYVYEILVWCVYYNSAMNPLIYAFFYQWFGKAIKLIV 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tmA_Octopamine_R	21..583	CDD:320191	115/562 (20%)
		TM helix 1	22..48	CDD:320191	11/25 (44%)
		TM helix 2	55..81	CDD:320191	15/25 (60%)
		TM helix 3	93..123	CDD:320191	13/29 (45%)
		TM helix 4	135..158	CDD:320191	8/23 (35%)
		TM helix 5	292..321	CDD:320191	10/28 (36%)
		TM helix 6	512..542	CDD:320191	11/29 (38%)
		TM helix 7	551..576	CDD:320191	12/24 (50%)
TAAR9	NP_778227.3	7tmA_TAAR6_8_9	33..322	CDD:320439	115/563 (20%)
		TM helix 1	34..60	CDD:320439	11/26 (42%)
		TM helix 2	67..93	CDD:320439	15/25 (60%)
		TM helix 3	105..135	CDD:320439	13/29 (45%)
		TM helix 4	147..170	CDD:320439	9/41 (22%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000250|UniProtKB:Q5QD04	174..187		4/96 (4%)
		TM helix 5	194..223	CDD:320439	10/29 (34%)
		TM helix 6	251..281	CDD:320439	12/40 (30%)
		TM helix 7	290..315	CDD:320439	12/24 (50%)