DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oamb and Adra2b

DIOPT Version :9

Sequence 1:	NP_001262774.1	Gene:	Oamb / 43982	FlyBaseID:	FBgn0024944	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_033763.3	Gene:	Adra2b / 11552	MGIID:	87935	Length:	448	Species:	Mus musculus

Alignment Length:	613	Identity:	159/613 - (25%)
Similarity:	236/613 - (38%)	Gaps:	216/613 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EPANLISLA----VLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFS 77
            ||.::.:.|    .:.|:.:..|.||.|||.||..|..||:..|.|:|:||.||:||...::|||
Mouse     5 EPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFS 69

  Fly    78 ATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIA 142
            ...|:...|.|...||.::||:||..||:||::|||||||||.||:|.:.|.|..:.::.|.:|.
Mouse    70 LANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIIL 134

  Fly   143 GIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPS 207
            .:|:::..|..|||:...||:       |:
Mouse   135 TVWLIAAVISLPPLIYKGDQR-------PE----------------------------------- 157

  Fly   208 PPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPP 272
                                                                            |
Mouse   158 ----------------------------------------------------------------P 158

  Fly   273 QNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRAINQGFKTTK 337
            ...||         |||..:..|:|.|::|||:.|..:|:..|.|||..|.|:
Mouse   159 HGLPQ---------CELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRS------------ 202

  Fly   338 GSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKI 402
            ..:|:|::           ||.|..:....|....        |.|:..              |:
Mouse   203 HCRGLGAK-----------RGSGEGESKKPHPAAG--------GVPASA--------------KV 234

  Fly   403 KISVSYPSSENISELAGHGDVGHERRQ--------------SGNAL---FAVHYNGTN------G 444
            ...||..||  :.|..||.....|:.:              :.:||   ......||:      |
Mouse   235 PTLVSPLSS--VGEANGHPKPPREKEEGETPEDPEARALPPNWSALPRSVQDQKKGTSGATAEKG 297

  Fly   445 RESTESQLYRQQQQHGVASSCYL--------QVGKGLPELARR---QSNTSEAGGSGHSRPANKK 498
            .|..|.::...:.|...||...:        |..:.|..|..:   ..|...|.|        :.
Mouse   298 AEEDEEEVEECEPQTLPASPASVFNPPLQQPQTSRVLATLRGQVLLSKNVGVASG--------QW 354

  Fly   499 MGRRNIKAQVKRFRMETKAAKTLAIIVGMFIFCWCPFFTMYIIRPFC-QDCVDPL-LFSVLFWLG 561
            ..||...::.|||..      .||:::|:|:.||.|||..|.:...| |.|..|. ||...||:|
Mouse   355 WRRRTQLSREKRFTF------VLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIG 413

  Fly   562 YCNSAVNPMIYALFSKDFRFAFKRIICR 589
            ||||::||:||.:|::|||.||:||:||
Mouse   414 YCNSSLNPVIYTIFNQDFRRAFRRILCR 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	55/124 (44%)
Oamb	NP_001262774.1	7tm_1	37..>181	CDD:278431	59/143 (41%)
Adra2b	NP_033763.3	7tmA_alpha2B_AR	7..435	CDD:320444	151/603 (25%)
		TM helix 1	14..40	CDD:320444	9/25 (36%)
		TM helix 2	47..73	CDD:320444	12/25 (48%)
		TM helix 3	85..115	CDD:320444	19/29 (66%)
		TM helix 4	127..150	CDD:320444	7/22 (32%)
		TM helix 5	169..198	CDD:320444	12/28 (43%)
		PRK12323	<209..354	CDD:237057	31/187 (17%)
		TM helix 6	362..392	CDD:320444	13/35 (37%)
		TM helix 7	403..428	CDD:320444	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910