DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oamb and adra1b

DIOPT Version :9

Sequence 1:	NP_001262774.1	Gene:	Oamb / 43982	FlyBaseID:	FBgn0024944	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_031754536.1	Gene:	adra1b / 100488806	XenbaseID:	XB-GENE-6047336	Length:	441	Species:	Xenopus tropicalis

Alignment Length:	675	Identity:	170/675 - (25%)
Similarity:	253/675 - (37%)	Gaps:	270/675 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NETECEDLIKSVKWTEPANLISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVAD 66
            |:|.....|.||..|. |.|:...:..||:|.:| ||.:||.:|..:.:||..||:.|||||:||
Frog    28 NQTFANKTIPSVNLTR-AMLLGFTLGAFISVAII-GNIMVIISVVTNKQLRIPTNYLIVNLAIAD 90

  Fly    67 LLVGLAVLPFSATWEVFKVWIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSI 131
            ||:...|||||||.|:...|:||.:.|.:|.|:||..|||||.:||.||:|||:.|...:.||:|
Frog    91 LLLSSTVLPFSATKEIVGYWVFGRILCDVWAAMDVLCCTASIFSLCTISIDRYIGVRHSLRYPTI 155

  Fly   132 MSTKKAKSLIAGIWVLSFFICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSI 196
            ::.|:....:.|:|:.|..|...||:|||:
Frog   156 VTRKRTILALLGVWMFSTVISIGPLLGWKE----------------------------------- 185

  Fly   197 KDQGEASLPPSPPHIGNGNAYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTET 261
                     |:||.
Frog   186 ---------PAPPD--------------------------------------------------- 190

  Fly   262 EMDLDLLNAPPQNRPQTISGSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTT 326
                                  .:.||:|.:..|.::|:|.|||||:.|:|..|.|:|..|.|.|
Frog   191 ----------------------TYVCEITTEIFYAIFSSLASFYIPLIVILVMYCRVYVVAKRIT 233

  Fly   327 RAINQGFKTTKGSKGIGSRFEEQRLTLRIHRGRGSNQQDSMHSNGSTQSTTTTLGTPSPERLSKY 391
            :.:..|.        :..|.:.:.||||||   ..|:||...:|...|
Frog   234 KNLEAGV--------MKERMDSKELTLRIH---CRNKQDDSPNNSKVQ----------------- 270

  Fly   392 ATRRLHHHDKIKISVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQ 456

Frog   271 ----------------------------------------------------------------- 270

  Fly   457 QQHGVASSCYLQVGKGLPELARRQSNTSEAGGSGHSRPANKKMGRRNIKAQVKRFRMETKAAKTL 521
                                              :::|      |..:..::.:|..|.||||||
Frog   271 ----------------------------------NNQP------RSALSLKLLKFSREKKAAKTL 295

  Fly   522 AIIVGMFIFCWCPFFTMYIIRPFCQDCVDPL-LFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKR 585
            .|:|||||.||.||||:..:....:....|: |..::|||||.||.:||:||...||:|:.||.|
Frog   296 GIVVGMFILCWLPFFTVLPLSSLSEHLTPPVTLEKIIFWLGYFNSCINPIIYPCSSKEFKRAFIR 360

  Fly   586 IICRCFCSRQSVSLKSS----RRGSDMSAIRIRARTPSITPSAAAHSFGDESELHHSEMSNDPRX 646
            |:...:.:|::.:.:.|    |.||.:|    .:|..||..::   .|.:.|:  .:.|:|.|..
Frog   361 ILKCQWGNRKNSAFRRSQYRPRPGSTVS----HSRKDSIEETS---QFINGSQ--RTIMTNAPSP 416

  Fly   647 RSFGPSSSSQSSLGGLRKTSLKVPV 671
            |....||..:..    |.:..|:||
Frog   417 RFLRKSSQPKEK----RTSEKKIPV 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	59/124 (48%)
Oamb	NP_001262774.1	7tm_1	37..>181	CDD:278431	60/143 (42%)
adra1b	XP_031754536.1	7tmA_alpha1B_AR	45..358	CDD:320449	138/563 (25%)
		TM helix 1	47..71	CDD:320449	9/24 (38%)
		TM helix 2	80..102	CDD:320449	14/21 (67%)
		TM helix 3	118..140	CDD:320449	12/21 (57%)
		TM helix 4	163..179	CDD:320449	4/15 (27%)
		TM helix 5	200..223	CDD:320449	10/22 (45%)
		TM helix 6	292..314	CDD:320449	16/21 (76%)
		TM helix 7	326..351	CDD:320449	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2667
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1095345at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.060